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🤖 | "Cells at Work! BLACK" Leukocyte looks like that anxious face ... Episode 9 Pre-cut


Photo "Cells at Work! BLACK" Episode 9 Pre-cut (C) Shigemitsu Harada, Issei Hatsuyoshi, Akane Shimizu / Kodansha

"Cells at Work! BLACK" Leukocyte looks so uneasy ... Episode 9 Preceding Cut

 
If you write the contents roughly
It depicts the harsh working environment of cells that work in a body whose body environment has become black due to repeated insufficiency and stress such as “drinking”, “smoking”, and “lack of sleep”.
 

From the TV anime "Cells at Work! BLACK", episode 2021 of the broadcast on Saturday, February 2, 20 "Abnormality, athlete's foot, willingness to work ..." → Continue reading

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Wikipedia related words

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Internal environment

Lack of sleep

Lack of sleep(Sleep deprivation) is a state of not getting enough sleep, there are both chronic and acute. Chronic sleep deprivation can cause fatigue, daytime drowsiness, reduced work efficiency, and weight loss or gain[1]. This can affect the brain and cognitive function[2]. However, sleep deprivation is paradoxically used as a treatment for depression because it increases energy and promotes arousal (sleep deprivation therapy).[3][4].

Few studies have compared the effects of acute sleep deprivation with chronic sleep deprivation.[2]. Complete lack of long-term sleep has not been confirmed in humans (Fatal familial insomniaexcept for).Micro sleepSeems inevitable[5]. Long-term sleep deprivation can cause death in animal studies[6].

Physiological effects

In general, lack of sleep results in:[7][8]

Impact on driving

The sleep-deprived driving risk is associated with driver fatigue in one in five serious motor vehicle injuries, according to a report by the American Academy of Sleep Medicine, which affects 5 people daily. The driver fell asleep and suffered 1 accidents related to sleep each year.[21]U.S. Highway Traffic Safety Administration estimates nearly 10 related traffic accidents[22]. The station recommends a 15- or 20-minute nap down the road to relieve drowsiness.[21].

Impact on health

Lack of sleepBlood glucose levelTo make it difficult to controlWeightIncreaseDiabetes mellitusIt becomes a factor to impair health such as inducing. There is no improvement effect even if you do "sleeping" to sleep together on holidays because if you continue to lack sleep again, you will not be able to control your blood sugar level[23][24].

Number

Means of interrogation

Lack of sleepInterrogationCan be used as a means oftortureWhether or not to be considered[25].

Imperial RussiaOf political prisonerstortureUsed as a means,Russian RevolutionAfterUSSRWas also inherited.

depression

In research, sleep deprivationdepressionHas the potential to be treated[4]. Depressed patients,Rem sleepSince there is a tendency for rapid eye movements before the onset of REM sleep, it seems that there is a therapeutic effect to alleviate the depressive effect by monitoring EEG during REM sleep and waking up during that period.[26]. With sleep deprivation, 60% of patients recovered promptly, but most of the cases recurred the next day. This effect Brain-derived neurotrophic factor(BNDF) increase[27]. It is believed that clonotypes are associated with the effects of sleep deprivation on people's mood: sleep deprivation leads to more depression in those who prefer morning, while those who prefer night to feel Showing improvement[28]. A comprehensive human metabolism assessment in 2014 found that sleep deprivation increased 27 metabolites 24 hours after waking up, and serotonin, tryptophan, and taurine could all contribute to antidepressant effects. Was[29]

Recurrence rate can be reduced by combining sleep deprivation therapy and medication[30]. manyTricyclic antidepressantSuppresses REM sleep, so there is evidence that may be associated with mood and sleep[31]..Similarly, tranylcypromine has been strongly shown to suppress REM sleep at adequate doses.

insomnia

Some common sleep disorders are:insomniaAgainstCognitive behavioral therapyIt has been shown to respond to (CBT-I).It has a built-in sleep restriction program to restore sleep homeostasis and promote normal sleep efficiency.[32].

Cause

The most common cause of sleep deprivation is sleepEnvironmentIs bad.The solution isGoing to bedAbout 1-2 hours before the timedarkI was in the room 45-60 minutes agoElectronicsStop using and at bedtimeEarplugWear androom temperatureIs to set to 18-20 degrees[33].

insomnia

One of six types of sleep abnormalitiesinsomniaAffects 21-37% of the adult population.[34][35] Symptoms include excessive daytime sleepiness, sleep dissatisfaction or worry, attention/concentration/memory problems, extreme mood changes or irritability, lack of energy or motivation, poor performance at school or at work.Tension headache,stomach acheHave been recognized.

Insomnia can be categorized as primary and secondary, or coexisting insomnia[36][37][38]. Primary insomnia does not result from medical, psychological or environmental causesSleeping disorderIs[39] Primary insomnia is mainly classified into 3 categories, including psychophysiological, idiopathic insomnia, and misidentification of sleep state (paradoxical insomnia).[36]. Psychophysiological insomnia is anxiety-inducing. Idiopathic insomnia generally begins in childhood and lasts for life. Its cause is a neurochemical problem in the part of the brain that controls the sleep-wake cycle, suggesting that either sleep deprivation signals or hyperactive wakefulness signals occur.[40]. Sleep state misperception is a state in which the patient sleeps adequately for diagnosis, but mistakenly recognizes that sleep is insufficient.

Secondary insomnia or comorbid insomnia coincides with other medical, neurological, psychological and psychiatric conditions. The cause is not always known[41].

Sleep apnea

Mental illness

The causal relationship between sleep loss and symptoms of mental disorders has been most extensively studied in patients with mood disorders.Bipolar disorderThe patientimpatientIt has been shown that sleep deprivation induces them in a manic state, as they are often preceded by a period of insomnia. Sleep deprivation may be the final common pathway in the development of mania[42]. Sleep loss is also considered to be both a manic sedative and a reinforcing factor.

At school

The US Sleep Foundation features a 6 paper that college and university students sleep an average of less than 1996 hours each night.[43]. The study reports that 70.6% of students sleep less than 8 hours and 27% of students are at risk of at least one sleep disorder[44]. Lack of sleep is common to university students in the first year, who are required to adapt to stress and social activities of university students.

TaiwanNational Chung Cheng UniversitySurvey conducted by the Department of Psychology concluded that freshmen had minimal sleep during the week[45].

1997 yearsUniversity of MinnesotaThe study compared students who went to school at 7:15 am with those who went to school at 8:40 am. It was found that students who went to school at 8:40 performed better than those who went to school earlier and slept longer on weekday nights.[22]. One in four high school students in the United States admit to sleeping at least once a week in class[46].

Typically in human adolescence,Circadian rhythmIt is known that sleep patterns change significantly accordingly. An EEG study showed adolescents with a 4% reduction in deep sleep (stage 50) in NREM sleep and a 75% reduction in peak delta amplitude. School schedules often cause less than optimal sleep for the majority of adolescents, as it conflicts with a corresponding delay in sleep stages[47].

治療

There are several common strategies for attempting to counteract the effects of sleep deprivation by increasing attention. In acute sleep deprivation, a short period of time to improve wakefulnesscaffeineAre often used. However, caffeine becomes less effective when taken daily[48].

Other strategies recommended by the American College of Sleep Medicine include prophylactic sleep, naps, other stimulants, and combinations thereof. But the only sure and safe way to combat sleep deprivation is to increase your sleep at night[49].

Recovery of cognitive function is quicker after acute and complete sleep deprivation than after chronic partial sleep deprivation[2].. Chronic sleep deprivation is more common in everyday life. Overnight sleep recovery may reverse the adverse effects of total sleep deprivation. Recovery sleep is more efficient than normal sleep,Sleep onset latencyBecomes shorter and deeper and increases REM sleep.

Source

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