Liver cancer(Cancer,British: Liver cancer) IsliverOccurred inMalignant tumorIs a general term for.

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Mostly the liver is the originPrimary liver cancerAnd cancer that started in other organs in the liverTransition officialMetastatic liver cancerIt can be divided into two.More primary liver cancerOrganization typeClassified by.

Most primary liver cancersHepatocellular carcinoma (hepatocellular carcinoma, abbreviation:HCC), So the word "liver cancer" may narrowly refer to "hepatocellular carcinoma".

Below, 2000WHOIt is classified and explained based on the material of "histological classification of tumours of the liver and intrahepatic bile ducts".

• Epithelial tumor
  • benign: Intrahepatic bile duct adenoma, etc.
  • Malignant
    • Hepatocellular carcinoma: Cancer that begins in hepatocytes, which are the parenchyma of the liver.In Japan, it accounts for about 90% of primary liver cancers.Many of the causesHepatitis C(Approximately 72%)Hepatitis B(About 17%),NASH,Alcoholic hepatitis, The cause is unknown.
    • Bile duct cell cancer: In the liverbile ductCancer that develops from.In Japan, it accounts for about 5% of primary liver cancers.
    • Other rare ones are the above mixed typeHepatoblastomaand so on.
• Non-epithelial tumor
  • benign: Hemangiomas, etc.
  • Malignant: Angiosarcoma etc.
• Other tumors: Solitary fibrous tumor, abbreviation:SFT) Such.
• Hematopoietic and lymphoid tumors
• Secondary tumor (metastatic liver cancer): Cancer of other organs that has spread to the liver.
• Tumor-like epithelial abnormalities : Hyperplasia,Dysplasiaetc.
• Other tumor-like lesions

Also in Europe and AmericaBile duct cell cancer TheCholangiocarcinomaIt is generally recognized that it is a part of the liver cancer, and hepatocellular carcinoma is almost hepatocellular carcinoma. I am dealing with it.

prevention

Viral hepatitisIt has been reported that treatment reduces the risk of carcinogenesis.

• Hepatitis B...Nucleoside-analogWhen the viral load is reduced, the carcinogenic rate decreases.^[1].
• Hepatitis C...interferonIt is known that the carcinogenic rate decreases when the virus is eliminated by α or β or temporarily reduced to an unmeasurable level.^[2].

治療

Treatment of hepatocellular carcinoma is laparotomyLaparoscopic surgery, Ablation by percutaneous puncture,catheterEmbolization usingRadiation therapy,chemical treatmentAnd so on^[3][4]..Treatment of metastatic liver tumor is surgerychemical treatmentIs the main.

Epidemiology

Liver cancer caused 2008 deaths annually in 70, with 140 million deaths worldwide.Lung cancer, 74 deathsGastric cancerIs the third cause of cancer death^[6].

GloballyEur-lex.europa.eu eur-lex.europa.euThe mortality rate from liver cancer is high in Mongolia.Hepatitis B virus (HBV),Hepatitis C virus (HCV) infection rate is high, and the general populationHBsAgPositive rates are reported to be 6.9% to 15.6% and HCV antibody positive rates are reported to be 10.7% to 36.3%.^[7].

footnote

Source

1. ^ Chen, CJ et al .: JAMA 295 (1); 65-73,2006
2. ^ J Infect Chemother. 2003 Dec; 9 (4): 333-40.
3. ^ Kojima, Hiroyuki; Tanigawa, Noboru; Kariya, Shuji; Komemushi, Atsushi; Shomura, Yuzo; Sawada, Satoshi; Arai, Eitatsu; Yokota, Yoshiro (2006-02). “A case of spontaneous regression of hepatocellular carcinoma with multiple lung metastases”. Radiation Medicine 24 (2): 139–142. two:10.1007 / BF02493281. ISSN 0288-2043. PMID 16715676. https://pubmed.ncbi.nlm.nih.gov/16715676/. 
4. ^ International Journal of Molecular Sciences. Vol.21 (3); 2020 FebruaryThe Biofunctional Effects of Mesima as a Radiosensitizer for Hepatocellular Carcinoma
5. ^ "WHO Disease and injury country estimates". World Health Organization (2009). 2009/11/11Browse.
6. ^ WHO (June 2010). “Cancer”. World Health Organization. 2011/1/5Browse.
7. ^ Examination of HBV / HCV markers in patients with hepatocellular carcinoma / hepatic dysfunction in Mongolia Tokai UniversitySchool of Medicine Toru Shizuma Retrieved April 2021, 4.
8. ^ Cancer information service "Cancer registration / statistics" (Report). National Cancer Center. https://ganjoho.jp/. 

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