Three companies including US Moderna start development of vaccine specialized for Omicron
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J & J also evaluated the effectiveness of the corona vaccine against the Omicron strain, and at the same time announced that it is developing a vaccine specialized for the Omicron strain.
[Reuters] – US Moderna, US Johnson & Johnson (J & J), German Biontech XNUMX ... → Continue reading
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COVID-19 vaccine(Covid 19 vaccine,British: COVID-19 vaccine) IsNew Coronavirus Infection (COVID-19) OfCauseウ イ ル スIsSARS coronavirus 2For (SARS-CoV-2)Human capitalToAcquired immunityAimed to providevaccine.New coronavirus vaccine,New corona vaccineAlso called.
2021 As of January,VaccinationFrom started to under development, there are multiple vaccines and manufacturers' vaccines (mRNA vaccine,DNA vaccine,Viral vector vaccine,Inactivated vaccine,RecombinantProteinvaccine,peptideVaccines, etc.).
Globally2020 Multiple from the end or the beginning of 2021PharmaceuticalInoculation of multiple COVID-19 vaccines developed and manufactured by companies has begun.Looking at the vaccination status of each country, some countries have succeeded in concluding vaccine procurement contracts at an early stage and have already been vaccinated on a large scale, while others have been delayed in vaccination and have hardly progressed. Exists ("" in the latter sectionVaccine security and inoculation statusSee).AustriaSome countries have decided to make vaccination mandatory..
Vaccines already by multiple pharmaceutical companiesClinical trialIt has already been done, and inoculation is being carried out all over the world.Efficacy is different for each vaccine ("EffectivenessSee).
For the inoculation status of each country and each region, see "Vaccine security and inoculation status"checking.
Some pharmaceutical companies that have yet to develop vaccines are still striving to develop a new type of COVID-19 vaccine.As of May 2021, 5, none of the Japanese pharmaceutical companies have succeeded in obtaining approval for their COVID-18 vaccine.
Background to the start of development and acceleration of development
Prior to the COVID-19 pandemicSevere acute respiratory syndrome(SARS)Middle East respiratory syndromeCauses diseases such as (MERS)CoronavirusIt was said that the development of various vaccine technologies could be accelerated in early 2020 because the knowledge about the structure and function of the vaccine was established... January 2020, 1, SARS-CoV-10Gene sequenceThe data isGISAIDBy March 3th of the same year, the global pharmaceutical industry announced its commitment to COVID-19 in a big way..
2020 eraAs COVID-19 spread rapidly on a global scale, research institutes and drug manufacturers in each country embarked on the development of new vaccines and the reassessment of existing vaccines developed for other viruses. It was.who(WHO)2020 Published a list of 5 plans in progress worldwide by May.Eight of these plans are already at that pointWestern,People's Republic of ChinaWas in the clinical trial stage in (China)..In addition, WHO is a framework for joint investment and purchase by each country in vaccine development.COVAX(Kobax)Was launched.
As of June 2020, it was reported that "for the first vaccine to be developed, there is a possibility of developing a type of vaccine that prevents aggravation and death rather than infection prevention."..Others have pointed out that the vaccine is not effective for the elderly..
Some companies are looking for new manufacturing methods for the production of vaccines for COVID-19. This is the traditionalChicken eggsbyInfluenza vaccineThis is because there is a risk that the productivity will be low and it will take time if the production method of is applied, and the virus injected into the egg may be mutated to reduce the effectiveness of the vaccine... In particular,DNA vaccine,mRNA vaccineDevelopment will proceed.
As of May 2020, WHO,Coalition for Epidemic Infectious Diseases Innovation(Coalition for Epidemic Preparedness Innovations, CEPI),andGates Foundation(GF) Was investing funding and organizational resources in anticipation of the need for several vaccines to prevent the continuation of COVID-19 infection..CEPI organizes a $ 20 billion global fund for rapid investment and development of vaccine candidates Showed in September 2020 that clinical data to assist in licensing may be available by the end of the year. On May 9, 2020, a teleson hosted by WHO (Long time special program), $ 40 billion pledges from 81 countries..At the same time, WHOII/Phase III clinical trialAlso announced the development of an international "solidarity trial" for the simultaneous evaluation of multiple vaccine candidates that have reached.
2020 year 11 month,バーレーンIs in ChinaShino FarmGiven the urgent marketing approval of the company vaccine,United Arab Emirates(UAE) followed. In December, with Bahrain英国Is ricePfizerApproved for emergency use of company vaccine, UAE andCanadaApproved for general use.
Status of clinical trials
In Phase III clinical trials, some COVID-19 vaccines are as high as 19% for the prevention of symptomatological COVID-95 infectionsEffectivenessIs shown. As of February 2021, 4 vaccines are available in at least one countryRegulatory authorityFrom for the general publicApproveding. Two typesRNA vaccine(Pfizer-BioNTech Vaccine,Moderna vaccine), 7 types of conventional typeInactivated vaccine(BBIBP-CorV,CoronaVac,Covaxin,,CoviVac,,), 5 typesViral vectorvaccine(Sputnik Light,Sputnik V,Oxford-AstraZeneca,Combidisia,Johnson & Johnson), 2 typesProtein subunit vaccine(EpiVac Corona,)..In total, as of March 2021, 3 vaccine candidates have been developed at various stages, with 308 cases.Under clinical researchOf these, 24 are Phase I trials, 33 are Phase I / II trials, and 16 are Phase III trials..
Production / distribution plan
In many countries, such as the elderlycomplicationsPlans are being implemented to give priority to those who are at the highest risk of infection and those who are at high risk of exposure to the virus, such as healthcare workers,..In addition, provisional use of a single dose is being considered to extend the vaccine to as many people as possible until the availability of the vaccine improves... As of May 2021, 5, according to official reports from health organizations in each country, 19 billion COVID-13 vaccines were administered worldwide...AstraZeneca-Oxford is expected to produce 2021 billion times in 30, Pfizer-BioNTech 13 billion times, Sputnik V, China National Pharmaceutical, Sinovac and Johnson & Johnson each 10 billion times.Moderna aims to administer 2021 million doses in 6 and Combidisia targets 5 million doses.. By December 2020, more than 12 billion vaccines have been pre-ordered from each country, High-income countries, which make up 14% of the world's population, buy about half of them.
For middle- and low-income countries that do not have sufficient economic power to procure vaccines from Western companiesPeople's Republic of China,Russian Federation,IndiaExports a large amount of vaccine, and it has been pointed out that it intends to expand its diplomatic influence...The Japanese government is providing the purchased AstraZeneca vaccine free of charge to Taiwan, Vietnam, Indonesia, Thailand, the Philippines, Malaysia and Brunei..
Vaccination has already started all over the world.For the inoculation status in each country and region including Japan, see "Vaccine security and inoculation status"checking.
Efforts to accelerate vaccination by giving various incentives and benefits to those who have been vaccinated Or a "vaccine" that proves that you have been inoculatedpassportThere is also a movement to issue..According to the guidance, fully vaccinated people can now participate in all indoor and outdoor activities without a mask and without physical distance...However, in July 2021, the Centers for Disease Control and Prevention advised everyone, including those who were fully vaccinated, to wear masks in public indoor areas where the virus was significantly or highly infected. bottom.
SARS and MERS
As of 2003, avian infectious bronchitis virus (infectious bronchitis virus),Canine coronavirusVaccines have been manufactured against several animal diseases caused by the coronavirus, such as feline coronavirus...Affect humansCoronavirusBranch Ofウ イ ル スPrevious projects for developing vaccines againstSevere acute respiratory syndrome(SARS) andMiddle East respiratory syndrome(MERS) was targeted. SARS And MERS Vaccines against non-humanWith animalsHas been tested.
According to studies published in 2005 and 2006, the identification and development of new vaccines and medicines to treat SARS was a priority for governments and health agencies around the world at the time... As of 2020, there are no cures or preventative vaccines that have been proven safe and effective against human SARS..
There is no established vaccine for MERS.. When MERS became widespread, existing SARS studies were thought to have the potential to provide useful templates for developing vaccines and treatments for MERS-CoV infection... As of March 2020, completed Phase I clinical trials in humans (DNAOne MERS vaccine (based), And three other vaccines are in progress, all of whichAdenovirusvectorTwo types (ChAdOx2-MERS, BVRS-GamVac) and one MVA vector type (MVA-MERS-S)..
2020 COVID-19 vaccine development
At the end of 19, when COVID-2019 began to spread worldwide-as of early 2020, there were no vaccines to prevent human coronavirus infection... After the detection of COVID-2019 coronavirus in December 12, COVID-19Gene sequenceWas released on January 2020, 1, triggering an urgent international response to expedite the development of preventative vaccines in case of an outbreak..
As of August 2020,who(WHO) is the causative virusSARS coronavirus 2He said he did not expect a vaccine against (SARS-CoV-2) to be available within 18 months... The global surge in COVID-2020 infection rates in early 19 stimulated international alliances and government efforts to urgently organize resources for the rapid production of multiple vaccines.In March, four vaccine candidates were included in the human evaluation ("Clinical trials started in 2020Refer to the table).
In April 2020, WHO will spend a total of 4 billion to develop three or more vaccines with different technologies and distributions.U.S. dollarEstimated.. By April 2020, "almost 4 companies and research institutes in 19 countries" will be in this virtualgold RushWas working on..Also in April, CEPI selected six vaccine candidates for COVID-4 for development through Phase II-III trials by the International Union, with three final vaccines. Estimates that it must be streamlined through regulation and quality assurance to obtain a license..Another analysis shows that 10 vaccine candidates require initial development at the same time, and 10 vaccine candidates require initial development at the same time before some of them are selected as the final path to licensing. I'm estimating.
July 2020, UK National Cyber Security Center (National Cyber Security Center), The United States and Britain of their respective governments and militaryIntelligence agencyAnd the security organization, Communications Security Establishment of Canada (Communications Security Establishment),United States Department of Homeland SecurityDirectorate General of National Protection and Programs (Cybersecurity Infrastructure Security Agency),US National Security Agency(NSA) is Russia's national supporthackerClaimed that it may have attempted to steal COVID-19 treatment and vaccine research from academic and pharmaceutical institutions in other countries.Russia denied it.
During 2020, the major changes in the overall COVID-19 vaccine development efforts from the beginning of the yearMultinational pharmaceutical industryIncreasing joint research with governments and many countries focusing on COVID-19 vaccineBiotechnologyCorporate diversity and growth.. According to CEPI, the general geographical distribution of COVID-19 vaccine development is:North AmericaOrganization accounts for about 19% of the world's COVID-40 vaccine researchAsiaとAustralia30% in Europe, 26% in Europe,South AmericaAnd there are several projects in Africa.
When vaccine development startsDistributed computingOf the projectFolding @ homeDue to the growing interest in, the computing power will be about 2020 in late March 3. EFLOPS, Achieved about 2020 EFLOPS in mid-April 4Became the world's first exaflop computing systemBESTSELLERSAll ofSuper computerAcquired the ability to exceed the total of.
Some organizations are forming international partnerships to accelerate vaccine development and prepare for distribution, some of which began raising US $ 2020 billion in early May 5, unprecedented in history. Promoting cooperation, accelerating research, and international communication on a scalewho(WHO) is also included.. WHO also has Covid-19 Vaccines Global Access to coordinate global vaccine development (COVAX)GAVIAnd in collaboration with CEPI Access to COVID-19 Tools (ACT) Accelerator Is the pillar of the vaccine.. In July, WHO announced that 7 countries, which make up up to 60% of the world's population, have agreed on a WHO COVAX program for the fair and equitable distribution of the final licensed vaccine. COVAX aims to accelerate the development and production of the COVID-165 vaccine and ensure that "access to licensed vaccines is provided fairly to all countries."Specifically, by the end of 19, participating countries will protect front-line healthcare workers and high-risk people and vaccinate the most vulnerable 2021% of the population. Guarantee that you will receive a guaranteed amount (provide up to 20 billion doses equally).
CEPI, in collaboration with international health authorities and vaccine developers, has created an additional US $ 20 billion fund.A global partnership between public, private, philanthropic and civil society organizations that has funded research and clinical trials of eight vaccine candidates for the foreseeable future (8-2020). The goal is to support some candidates for full development..United Kingdom, Canada,Belgium,Norway,Switzerland,Germany, NetherlandsHas already donated US $ 9 million, A private charity specializing in vaccine research and distributionBill & Melinda Gates Foundation(Gates Foundation) has donated US $ 2 million.
From London, England, June 2020, 6G7andG2035 of the countriesHead of StateAmong private and government representatives from 52 countries, includingVirtualThe summit was adjusted and US $ 88 billion was raised.Global Alliance for Vaccines and Vaccinations (GAVI)By2025 Prepare for vaccines for 3 million children in developing countries by..The main donation is US $ 16 billion from the Gates Foundation And the UK government for five years, including £ 5m a year (about US $ 3 billion in June 3000).
As of December 2020, US $ 12 billion has been raised by ACT Accelerators, nine vaccine candidates have been funded by COVAX and CEPI, and 24 countries are working on final vaccine deployment plans..
Coalition for Epidemic Control Innovation (CEPI)
Coalition for Epidemic Infectious Diseases InnovationIs the Norwegian government, the Indian government,Bill & Melinda Gates Foundation, And charitable trust organizationsWelcome TrustFunded in 2017World Economic Forum(DavosPublic institutions, private institutions, which were established at the conference)CharityAnd a global collaboration between civil society.Japan OfMinistry of Health, Labor and WelfareHas also been involved in the foundation and contributed since 2017.
On January 2020, 1, CEPI began work on vaccine development by the following three research teams, with at least one vaccine.Clinical trialAnnounced that it will start by June.. He also conducted clinical trials on humans in the summer, and said that approval of the vaccine would be as early as this year.
- US drug/vaccine developmentModerna, Inc.(English) (MRNA.O) andNational Institute of Allergy and Infectious Diseases (NIAID) cooperation
- Pharmaceutical company Inovio Pharmaceuticals, Inc. (INO.O)
- HoweQueensland UniversityTeam
Inovio has MERS' most advanced vaccine candidate INO-4700, The virus could be designed within 3 hours after the DNA sequence of the virus was published. Up to $ 900 million (about 9 million yen) from CEPISubsidyIn the early summer of 2020Middle East-AfricaLocalPhase II clinical trialGoing into Wants to conduct large-scale clinical trials in China by the end of the year.
XNUM X Month X NUM X Day,ModernaIs a safety study of administering the COVID-19 vaccine under development to humans (Phase I study) For US allergiesInstitute of Infectious Diseases (NIAID) Shipped to.Clinical trials in humans are expected to begin within two months, but may take a year and a half to become generally available..
August 2020, 3,Osaka UniversityDrug discovery companyAngesIt is,DNAPlasmidUtilizing technologyDNA vaccineWas jointly developed with Osaka UniversityTakara BioAnnounced that it will manufacture.. The clinical trial will start on June 6, the same year, and will be conducted for 30 people by the end of July..
August 2020, 5,Shionogi PharmaceuticalIs a subsidiary of UMN PharmaNational Institute of Infectious DiseasesIn collaboration with, it announced that it is aiming to start clinical trials within the year. The clinical trial is scheduled to start in 2020 at the earliest. It is expected to be launched in the market in the fall of 2021, with the goal of producing 3,000 million people by the end of the same year..
August 2020, 6,Kyushu UniversityIs from Kyushu UniversityVenture companyJointly announced that it has succeeded in developing a protein that is a candidate for a vaccine for the new coronavirus... Aiming to start clinical trials of vaccine from 2021.
While the development of the vaccine was urgent as of August 2020, experts (at that time) were concerned that "the effect of preventing the infection itself is difficult to prove."Also, of the Institute of Medical Science, University of TokyoKen IshiiThe professor complains, "The more you hurry (vaccine development), the more you neglect to guarantee safety."..In response to this concern, Dr. Sotaro Mine, a postdoctoral fellow at the National Research Institute of the United States, who specializes in virology and immunology, said, "Animal experimentationBased on the results such as, "I think that it has (infection prevention effect)." It has said.
Even in Japan, "fever, etc. at the clinical trial stage"Side effectsCan be seen in some casesAs of December 2020, 12, "Pfizer / BioNTech vaccine has been reported to anaphylaxis in 20 people (27 people per million people) when inoculated to 6 people."According to a report on January 2020, 1, "Moderna's vaccine had anaphylaxis in 23 people (400 per million people) after 10 million people were vaccinated, and all patients recovered thereafter. Was reported.
In Japan, Pfizer submitted an application for approval to the Ministry of Health, Labor and Welfare on December 2020, 12, and domestic manufacturers and universities are developing it with the aim of putting it into practical use. It is a goal and has not been put into practical use yet., Was said.
On February 2021, 2, AstraZeneca filed an application for approval with the Ministry of Health, Labor and Welfare..
February 2021, 2, Pfizer's corona vaccine "CommunityWas approved, and was officially approved on February 2021, 2...The legal name of the vaccine is "Coronavirus-modified uridine RNA vaccine (SARS-CoV-2)"..
On May 2021, 5, the special approval of Astra Zeneca's corona vaccine "Bakiszebria" and Moderna's corona vaccine "COVID-20 Vaccine Moderna" (later renamed to "Spikebacks") was approved, and 19 Officially approved as a special case on May 2021st..The legal name for AstraZeneca's viral vector vaccine is "Coronavirus (SARS-CoV-2) vaccine (recombinant saladenovirus vector)"...However, although the Moderna vaccine was targeted for public inoculation following Pfizer (used at large venues described below), the AstraZeneca vaccine appears to be a side reaction in other countries.ThrombosisAlthough it was approved by the regulatory affairs, it was excluded from public inoculation due to the outbreak of..After that, on August 8, the same year, it was added to the target of public inoculation for people aged 3 and over in principle..
On July 2021, 7, Daiichi Sankyo announced that it would start clinical trials of the mRNA vaccine by the end of the year...Because other vaccinations have already started in JapanplaceboDue to ethical issues in comparison with other vaccines, a recessive trial will be conducted to compare the difference in efficacy with other vaccines..
December 2021, 12, Takeda Pharmaceutical Company Limited is an American biotechnology companyNova BucksAnnounced that it has submitted a manufacturing and marketing approval application to the Ministry of Health, Labor and Welfare for the recombinant protein vaccine..
On January 2020, 1, an official from the China Center for Disease Control and Prevention (CDC) said it had begun development of the vaccine... Aug. 1,GuangzhouRussiaConsulateChina announced that the new coronavirus genome was provided from China to Russia, and China and Russia started joint vaccine development.
The clinical trial of the developed vaccine was approved in China on March 3 (although it is unknown whether it is the same as above), with Chen Wei as the leader.Chinese PLA Military AcademyMilitary Medical Research InstituteResearchers start clinical trials.. On June 3China Central TelevisionAlso reported.
March 3, with the Institute of Biological Engineering, Academy of Military Medical SciencesIs a new type of coronavirus vaccine developed independently (Adenovirus(Media) started the first clinical trial to 108 people..The project manager is Chen Wei Major GeneralSo, using the replication defective human type 5 adenovirus as a medium, S antigen of the new virus is made..Seven Chen Wei teams have already been vaccinated to prevent infection..Maj. Gen. Chen has a PhD in viral vaccine research and has previously received anti-SARS virus preparations andEbolaHas been announced to have succeeded in developing a vaccine for.
On May 2020, 5, CanSino Biologics reported that it was the first in the world to confirm the effect on humans in a phase 25 clinical trial of a viral vector vaccine that started in March of the same year... Aug. 6,People's Republic of China Central Military CommissionIs a domestic vaccine "Ad5-nCoVUseChinese PLADecided to authorize only to.. From July 7, emergency use of the vaccine was started for medical professionals..
May 2020, 12, ChineseShino FarmThe company is a domestic vaccine "BBIBP-CorVThe efficacy of the vaccine was set at 79.34%, and the vaccine was approved before China on December 12, the same year.Mohammed bin Rashid Earl McTumAnnounced lower than the 86% announced by the United Arab Emirates..The following day, the 31st, China's National Pharmaceutical Products Administration approved China National's "BBIBP-CorV"..
In mid-August 2020, the Russian government approved the domestically manufactured vaccine and announced that it plans to start vaccination for medical professionals from October... Then on August 8thVladimir PutinThe presidentGamareya Memorial National Center for Epidemiology and MicrobiologyDomestic vaccine "Gam-COVID-VacAnnounced that it was the first in the world to approve (Sputnik V)..
The United States of America
United States Federal GovernmentWill invest more than $ 2020 billion in 100 to subsidize vaccine research and manufacturing and pre-purchase contracts.Operation Warp Speed(Ultra-high-speed operation) started.US Biomedical Advanced Research and Development Agency TheAstraZeneca(UK)SanofiWe also support vaccine development by pharmaceutical companies in other countries such as (France)..
January 2020, 1, major US pharmaceutical and daily necessitiesJohnson & Johnson (J & J) announced that it has begun development of the COVID-19 vaccine.EbolaApply the technology used to develop the vaccine. This vaccine is currentlyEur-lex.europa.eu eur-lex.europa.euとRwandaHas been administered in.. "We have already put a lot of researchers into vaccine development and are confident that we will be able to achieve some results within a month. We already have a mass production system for the global market, so once the vaccine is complete, We can ship 1 million units within a year. ".
August 2020, 3,National Institutes of HealthIt is,National Institute of Allergy and Infectious DiseasesAnd the mRNA vaccine developed by the biopharmacy company ModernaClinical trialAnnounced that it reached. The clinical trial isState of WashingtonSeattleBeginning in the city, From multiple clinical trial participants by May 5, the same yearantibodyI was able to confirm..We plan to supply 1 to 5 billion doses to the world in one year..
PfizerVaccine will be available in 2020. Aim to inoculate hundreds of millions of people by 2021. If the vaccine is completed in Japan, it will be supplied to Japan for 2021 thousand doses by June 6.Japanese GovernmentIs basically agreed with..Later, data from early clinical trials were released on November 2020, 11, with preventive efficacy exceeding 9%...In response to this, we will apply for approval to the US Food and Drug Administration by the end of November 2020..
The Novabax vaccine is targeted for production of 1 million doses a year.Production is in the United StatesFujifilmIn cooperation with a subsidiary, in JapanTakeda PharmaceuticalWill manufacture and sell from the drug substance.
AstraZeneca Oxford Universityと共同でワクチン開発を開始し、そ2020年4月より臨床試験を開始した。同年9月以降、翌21年にかけて10億回分の生産が可能と目され、5月の時点で既に4億回分（アメリカ3億回分、イギリス1億回分）の供給を9月から開始することが予定されていた..After that, the supply plan was increased to 20 billion times, and it was basically agreed with the Government of Japan that Japan would be supplied with 1 million times, of which 2,000 million times would be supplied by March 3,000... Regarding the clinical trial, it was confirmed that some participants were suspected of having a serious adverse reaction.May 9Was interrupted from Revealed that it resumed on September 9th.
However, concerns have since been raised in each country regarding the AstraZeneca vaccine. On January 2021, 1 in FranceEmmanuel MacronThe president said that the company's vaccine is almost ineffective for older people over the age of 60-65., The country's health authorities recommended not to inoculate elderly people aged 2 and over on February 2, and German, Italian and Swedish health authorities also recommended not to inoculate elderly people.. However,European Medicines Agency(EMA) recommended vaccination for adults of all ages.
Also in March 2021 after vaccination with AstraZeneca vaccinethrombusGermany, France, Italy, Spain, Denmark due to reports of adverse reactions such as, Iceland, Norway,Netherlands,Thailand There were many countries that suspended inoculation. On March 3, WHO announced a comment to continue vaccination, as no causal relationship was found between the company's vaccine and the occurrence of blood clots...In response to this, inoculation was resumed in France and Germany..
AstraZeneca clinical trials confirmed 79% efficacy, announced March 2021, 3.. HoweverNational Institute of Allergy and Infectious DiseasesPointed out that it may have contained old, incomplete clinical trial data and requested that it provide up-to-date and accurate information.AstraZeneca also announced that it will provide the latest data within 48 hours..As a result, the effectiveness was corrected to 76%..
February 2020, 2 in FranceSanofiThe United StatesMinistry of Health and Welfare Announced that it aims to rapidly develop a recombinant vaccine for COVID-19 in collaboration with the Biomedical Advanced Research and Development Agency (BARDA) of (HHS)...Also supported by the Biomedical Advanced Research and Development Agency.
IndiaInoculation of two domestic vaccines was started on January 2, 2021.India has one of the world's largest vaccine manufacturers, the Serum Institute of India (SII), which exports but relies on imports from the US and EU for raw materials..
Domestic pharmaceutical companies distribute in JapanCompanyJointly developed by SII and manufactured by SIIKobaksin' Developed by AstraZeneca and by Barrat BiotechLicense productionTo "Kobi ShieldThe former did not show data to prove its effectiveness at the approval stage...Efficacy of 81% was evaluated in subsequent clinical trials.
TaiwanThen,(Chinese: Vaccine seedling biologic,Hsinchu Prefecture)ButNational Institutes of HealthDeveloped with the cooperation ofIn response, an emergency use authorization was issued in July 2021. Inoculation started on August 7, 2021Tsai EnglishPresidentWas vaccinated early in the morning of the same day.
Tsai Ing-wen states that in the past it was difficult to import vaccines except for private procurement and grants from Japan and the United States due to China's obstruction..
Southeast Asian countries
Eur-lex.europa.eu eur-lex.europa.euNanogen Pharmaceutical BiotechnologyVietnam Army Medical University"Nanocovacs" is under development in collaboration with, in February 2021Second stage clinical trial, Started the final stage clinical trial on June 6.
Iran's supreme leaderAlly HarmenayThe vaccine that was inoculated on June 2021, 6 was urgently approved in the same month among several vaccines being developed in Iran, according to Iranian state media..
Type of vaccine
As of January 2021, nine different technology platforms (many candidate technologies remain undefined) are under research and development to create an effective vaccine against COVID-1..
Most of the vaccine candidate platforms in clinical trials are major COVID-19 infectionsantigenCoronavirus asSpike proteinAnd its variants.. The platform developed in 2020Nucleic acidTechnology (Nucleoside modified messenger RNAandDNA),Non-replicating viral vector,peptide,Recombinant protein,Attenuated virus,and so on.
Many vaccine technologies being developed for COVID-19 use a "next generation" strategy to improve the accuracy of the COVID-19 infection mechanism, unlike vaccines already used to prevent influenza. doing..Some synthetic vaccines utilize 2P mutationsSpike proteinImmobilizes the prefusion structure and stimulates the immune response before the virus attaches to human cells..Vaccine platform under development increases the flexibility of antigen manipulation for healthcare professionals, the elderly, children, pregnant women, It can be expected to have an effect of targeting the infection mechanism of people who are susceptible to COVID-19 infection, such as those who have decreased infection..
Vaccine platform used in SARS-CoV-2.For all virus vaccinesAttenuated virusとInactivated virusBoth are included.Protein andpeptideSubunitVaccines are usually used to increase immunogenicityAdjuvantCombined with. In SARS-CoV-2 vaccine development, trimericSpike proteinWhole or receptor binding region (RBDThe emphasis is on using components such as).Multiple non-replicationsViral vector vaccineHas been developed, especiallyAdenovirusIs focused on.On the other hand, the construct of the replication viral vector is not so important.
RNA vaccineToRNAIs included and when introduced into the organizationMessenger RNAActs as (mRNA), causing cells to make foreign proteins,Adaptive immune responseStimulate and respondPathogen,cancer cellTeach the body how to identify and destroy. RNA vaccineNucleoside modified messenger RNAIs often used, but not always. Delivery of mRNA protects RNA strands and aids absorption into cellsLipid nanoparticlesAchieved by co-formulating the molecule..The development of this technologyUniversity of PennsylvaniaImmunologist,Drew WeissmanとKariko Catalinby.
RNA vaccine is the first COVID-19 vaccine approved in the United States and the European Union.. As of January 2021, this type of licensed vaccine isPfizer-BioNTech Vaccine とModerna vaccine Is. As of February 2021, in the EU, CureVac RNA vaccine awaits approval.
Severe allergic reactions are rare. In December 2020, the first 12 doses of Pfizer-BioNTech COVID-19 vaccine resulted in 1,893,360 severe allergic reactions, 175 of which.AnaphylaxisMet.. Only 2020 reports of anaphylaxis were reported in 12 doses of the modelna COVID-2021 vaccine in December 1 and January 19..Lipid nanoparticlesIs most likely involved in an allergic reaction.
Adenovirus vector vaccine
These vaccines contain DNA encoding the SARS-CoV-2 proteinAdenovirus-Non-replication using a shellViral vectorIs an example of.. Vaccines using viral vectors against COVID-19 have the non-replicating nature of producing only antigens that elicit a systemic immune response rather than producing new viral particles.
Sputnik V uses the same Ad26 as the Johnson & Johnson vaccine for the first time and the same Ad1 as Combidisia for the second time, with the same efficacy as a single dose, 5 A complete study has been conducted to see if a single dose has the same effect.
Inactivated virus vaccine
As of January 2021, in ChinaCoronaVac,BBIBP-CorV, IBP-CorV, IndiaCovaxin, Russian CoviVac Is licensed.Vaccines in clinical trialsKM Biologics,Valneva vaccineThere is.
Subunit vaccineOne or more without introducing the entire particle of the pathogenantigenTo present.Antigens are oftenProtein subunitHowever, any molecule can be used as long as it is a fragment of a pathogen..
As of April 2021, only this type of vaccine has been approved.Peptide vaccine OfEpiVac Corona と There are two.For vaccines that are pending approval,Novavax COVID-19 vaccine When,(Conjugate vaccine),There is.Was previously in clinical trials but was discontinued because subsequent HIV tests revealed that it could cause false results..
Self-propagating RNA vaccine
It is a self-propagating or replicating vaccine called a self-propagating RNA vaccine or a self-replicating RNA vaccine.It is a next-generation RNA vaccine that proliferates proteins that increase RNA in the body after inoculation and increases RNA by itself. In the case of VLP Therapeutics Japan vaccine, it grows by itself, so if there are 127g of replicon particles, it is calculated that a vaccine that can be inoculated to the entire population of Japan can be made.In addition, it is said that it can be stored for 4-1 months in an environment of 2 ° C... VLP Therapeutics Japan,Osaka City University,National International Medical Research Center,Institute for medical infrastructure, health and nutrition,Oita UniversityEtc. are under development..In addition, Elixirgen Therapeutics, Inc. (Elixirgen Therapeutics) in Baltimore, Maryland, USA has developed a self-replicating RNA vaccine "EXG-5003", and in Japan, Fujita Medical University (Toyoake City, Aichi Prefecture). Phase 1/2 clinical trials have been started at.
Oral vaccines and nasal vaccines are also being developed and researched.
Lifetime immunityVaccines are also being researched and developed with the aim of acquiring the vaccine, which is a smallpox vaccine researched and developed by the Tokyo Metropolitan Institute of Medical Science.Vaccinia virusSARS-CoV-2 gene incorporated into a further attenuated DIs strainLive vaccine,, Institute of Industrial Science, University of TokyoMeasles virusIs researching and developing a live genetically modified vaccine using .
Scientists investigated whether existing vaccines for unrelated diseases could activate the immune system and reduce the severity of COVID-19 infection...For tuberculosisBCG vaccineThere is experimental evidence that has a non-specific effect on the immune system, but there is no evidence that this vaccine is effective against COVID-19..
Vaccine efficacy(Vaccine efficacy) is a control study comparing the risk of illness in vaccinated subjects to the risk of illness in unvaccinated subjects...0% efficacy means that the vaccine does not work (placeboSame as).A 50% efficacy means that vaccinated people are half as infected as unvaccinated people.
It is not easy to compare the efficacy of different vaccines because clinical trials were conducted with different populations, regions and different virus variants... Vaccine for COVID-1967% may be enough to delay the pandemic, but this is necessary for the vaccine to prevent infectionSterilization immunityIt is premised on giving (the action of the immune system to eliminate the virus before infection).Vaccine efficacy reflects disease prophylaxis and may be highly infectious in asymptomatic individuals, making it an inadequate indicator of SARS-CoV-2 infectivity..US Food and Drug Administration(FDA) andEuropean Medicines Agency(EMA) has set a cutoff value of 19% for the efficacy required for approval of the COVID-50 vaccine...A realistic mass vaccination rate of 75% is targeted and actualBasic reproduction numberThe efficacy required for the COVID-19 vaccine is expected to be 70% or more to prevent the epidemic and 80% or more to extinguish the epidemic without taking measures such as social distance. ing.
In the calculation of efficacy, symptomatological COVID-19 is commonly referred to as PCR (Polymerase chain reaction) The test is positive andAlthough defined as having at least one or two symptoms in the defined list of, the exact specifications will vary from study to study.By countrySARS-CoV-2 mutant strainBecause of the different prevalence of, the study site also affects the reported efficacy.The following range is 95% unless otherwise statedConfidence intervalAnd all values are for all subjects regardless of age.Efficacy for severe COVID-19 is of paramount importance, hospitalization and death are public health burdens, and prevention is prioritized...The vaccines that have been approved and approved have shown the following efficacy.
|vaccine||Effectiveness of COVID-19 by severity||Clinical trial location||Reference|
|Mild or moderate[Note 1]||Serious symptoms without hospitalization or death[Note 2]||Serious symptoms with hospitalization and death[Note 3]|
|Moderna vaccine||~ 94% (89–97%)[Note 4]||~ 100%[Note 5]||~ 100%||United States|||
|Pfizer BioNTech Vaccine||~ 95% (90–98%)[Note 6]||Not reported||Not reported||Multinational|||
|Sputnik Light||~ 79%||Not reported||Not reported||Russia|||
|Sputnik V vaccine||~ 92% (86–95%)||~ 100% (94–100%)||~ 100%||Russia|||
|Oxford-AstraZeneca Vaccine||~ 81% (60–91%)[Note 7]||~ 100% (72–100%)||~ 100%||Multinational|||
|~ 76% (68–82%)[Note 8]||~ 100%||~ 100%||United States|||
|BBIBP-CorV||~ 79%||~ 100%||~ 100%||Multinational|||
|CoronaVac||~ 78%||~ 100%||~ 100%||Brazil|||
|Nova Bucks Vaccine||~ 89% (75–95%)||~ 100%[Note 9]||~ 100%[Note 9]||United Kingdom|||
|~ 60% (20–80%)||~ 100%[Note 9]||~ 100%[Note 9]||South Africa|
|Johnson & Johnson Vaccine||~ 66% (55–75%)[Note 10][Note 11]||~ 85% (54–97%)[Note 12]||~ 100%[Note 13]||Multinational|||
|~ 72% (58–82%)||~ 86% (-9–100%)||~ 100%||United States|
|~ 68% (49–81%)||~ 88% (8–100%)||~ 100%||Brazil|
|~ 64% (41–79%)||~ 82% (46–95%)||~ 100%||South Africa|
|Covaxin||~ 78% (61-88%)||~ 100%||~ 100%||India|||
|Convidicea||~ 66%||~ 91%||Not reported||Multinational||[Unreliable medical source?]|
- ^ Mild symptoms: fever, dry cough, tiredness, myalgia, joint pain, sore throat, diarrhea, nausea, vomiting, headache, olfaction, tastelessness, stuffy nose, epistaxis, conjunctivitis, rash, cold, dizziness Such.Moderate symptoms: mild pneumonia.
- ^ Serious symptoms that do not lead to hospitalization or death of an individual are any of the following serious respiratory symptoms measured at rest at any time during the observation period (pneumonia, deep vein thrombosis, dyspnea): , Hypoxia, persistent chest pain, loss of appetite, confusion, or fever above 38 ° C, but not persistent or severe enough to lead to hospitalization or death).Respiratory rate of 30 beats / minute or higher, heart rate of 125 beats / minute or higher, oxygen saturation (SpO2) of 93% or lower (indoor air above sea level), or oxygen partial pressure / inspiratory oxygen partial pressure (PaO2 / FiO2) Is less than 300mmHg.
- ^ Serious symptoms that cause hospitalization or death include those requiring hospital treatment or death: dyspnea, hypoxia, persistent chest pain, loss of appetite, confusion, 38 ° C or higher Fever, dyspnea, renal failure, multiple organ failure, sepsis, shock.
- ^ Mild / Moderate COVID-19 symptoms observed in the Moderna vaccine trials, were only counted as such for vaccinated individuals if they began more than 14 days after their second dose, and required presence of a positive RT-PCR test result along with at least two systemic symptoms (fever above 38ºC, chills, myalgia, headache, sore throat, new olfactory and taste disorder) or just one respiratory symptom (cough, shortness of breath or difficulty breathing, or clinical or radiographical evidence of pneumonia) ).
- ^ Severe COVID-19 symptoms observed in the Moderna vaccine trials, were defined as symptoms having met the criteria for mild / moderate symptoms plus any of the following observations: Clinical signs indicating of severe systemic illness, respiratory rate ≥ 30 per minute, heart rate ≥ 125 beats per minute, SpO2 ≤ 93% on room air at sea level or PaO2 / FIO2 <300 mm Hg; or respiratory failure or ARDS, (defined as needing high-flow oxygen, non-invasive or mechanical ventilation, or ECMO), evidence of shock (systolic blood pressure <90 mmHg, diastolic BP <60 mmHg or requiring vasopressors); or significant acute renal, hepatic, or neurologic dysfunction; or admission to an intensive care unit or death. in the trials, compared with 30 severe cases reported in the placebo group (incidence rate 9.1 per 1000 person-years).
- ^ Mild / Moderate COVID-19 symptoms observed in the Pfizer-BioNTech vaccine trials, were only counted as such for vaccinated individuals if they began more than 7 days after their second dose, and required presence of a positive RT-PCR test result along with at least one of the following symptoms: fever; new or increased cough; new or increased shortness of breath; chills; new or increased muscle pain; new loss of taste or smell; sore throat; diarrhea; or vomiting.
- ^ When the dosing interval is 12 weeks or more. At intervals of less than 6 weeks, efficacy was approximately 55% (33-70%).
- ^ The dosing interval is 4 weeks.Efficacy is said to be "prevention of symptomatological COVID-19".
- ^ a b c d No cases were detected in the study.
- ^ For medium.
- ^ Efficacy reported 28 days post-vaccination for the Johnson & Johnson single shot vaccine. A lower efficacy was found for the vaccinated individuals 14 days post-vaccination.
- ^ The source does actually say negative 9.
- ^ No hospitalizations or deaths were detected 28 days post-vaccination for 19,630 vaccinated individuals in the trials, compared with 16 hospitalizations reported in the placebo group of 19,691 individuals (incidence rate 5.2 per 1000 person-years) and 7 COVID-19 related deaths for the same placebo group.
Vaccine effectivenessIn a real-world study of (vaccine effectiveness), certain vaccines have shown COVID-19 infection, symptoms, hospitalization, and death in large populations of vaccinated individuals under non-ideal routine conditions. Measure how much you could prevent.
- Centers for Disease Control and PreventionPfizer-BioNTech and Moderna Covid-19 vaccines provide highly effective protection, according to the report...In the actual environment, the effectiveness of the complete immunity (more than 2 days after the second administration) mRNA vaccine is 2% and partial immunity (14) against SARS-CoV-90 infection regardless of the symptom status. The vaccine efficacy was 1% at least 14 days after the second dose and before the second dose.
- 104 healthcare workers working in 15,121 UK hospitals were all COVID-19 before the surveyantibodyWas negative, but from December 2020, 12 to February 7, 2021Lineage B.1.1.7Twice a week during the period when was circulating as the dominant mutant strainReverse transcription-polymerase chain reaction (RT-PCR) testで追跡調査を行った。この研究では、ワクチンを接種した90.7%のコホート（母集団）と、ワクチンを接種しなかった9.3%のコホートの陽性結果を比較し、ファイザー-バイオンテック社のワクチンは、全ての感染症（無症候性を含む）を、1回目の接種から3週間後には72%（58-86%）減少させ、2回目の接種から1週間後には86%（76-97%）減少させたことがわかった.
- From January 2021th to March 1th, 17, during the period when strain B.3 was circulating as a dominant mutant strain.IsraelA study of the general population of Pfizer found that the Pfizer vaccine reduced asymptomatic COVID-19 infections by 94% and symptomatic COVID-19 infections by 97%..
- America'sMayo ClinicA study of preoperative patients showed that the mRNA vaccine was 80% protective against asymptomatic infections..
- Director of China Disease Control CenterGao FuAdmitted at a meeting held on April 2021, 4, that Chinese vaccines were "not very protective."Private companyShinobuCompany developedCoronaVacVaccineBrazilA clinical trial in Japan found that the efficacy rate was only 50.4%.TurkeyAnother study conducted in Japan showed 83.5% effectiveness.State-ownedShino FarmAccording to the company, the efficacy rates of the two vaccines are 2% and 79.4%..
|vaccine||Effectiveness of COVID-19 by severity||Survey country||Refs|
|Pfizer-BioNTech||~ 86% (76-97%)||Not reported||United Kingdom|||
|~ 90% (68-97%)||~ 100%[I]||United States|||
|~ 94%||~ 97%||Israel|||
|Moderna||~ 90% (68-97%)||~ 100%[I]||United States|||
|CoronaVac||Not reported||~ 67% (65-69%)||~ 80% (73-86%)||Chile|||
|Sputnik V||Not reported||~ 98%||Not reported||Russia|||
Efficacy for mutant strains
Induced by current COVID-19 vaccineantibodyMedium or completely to the responseResistanceIf a SARS-CoV-2 mutant with SARS-CoV-XNUMX appears, it may be necessary to change the vaccine...Studies have shown that many vaccines developed for early strains are less effective against some mutants of symptomatological COVID-19... As of February 2021, the U.S. Food and Drug Administration (FDA) believes that all FDA-approved vaccines maintain a protective effect on circulating strains of SARS-CoV-2..
Mutant strains are concerned about the risk of escaping from neutralizing antibodies acquired by recoverers and vaccinated individuals, but a study by the National Institute of Infectious Diseases and the Japan Medical Research and Development Organization conducted a study of new coronavirus infection (COVID). -19) It was discovered that the total amount of neutralizing antibody in the recoverer declines with time, but an antibody that cross-binds to the mutant strain is acquired, and the quality of this antibody (neutralizing specific activity / crossability) improves with time. bottom.This phenomenon will be an important finding in vaccine strategies for mutant strains. .
Alpha strain (Strain B.1.1.7)
In December 2020, a new mutant strain, strain B.12, was identified in the United Kingdom...Initial results showPfizer-BioNTech VaccineとModerna vaccineBoth suggest protection against UK mutants.
In one studyOxford-AstraZeneca VaccineShowed 1.1.7-42% efficacy against B.89 and 1.1.7-71% efficacy against mutant strains other than B.91...According to preliminary data from clinical trialsNovavax vaccine~ 96% for the original mutant strain, ~ 1.1.7% for B.86,South AfricaIt has been shown to have a symptomatological improvement effect of ~ 1.351% against B.501 (2.V60 mutant strain)..
Beta strain (Strain B.1.351 / 501.V2 mutant)
Moderna has begun testing a new vaccine to tackle South African strain B.1.351 (501.V2 mutant).. On February 2021, 2, Pfizer announced that the neutralizing activity of B.17 was reduced to two-thirds, but said that the vaccine's disease-preventing effect on this mutant could not yet be claimed... From patients vaccinated with Modelna and Pfizer against B.1.351serumDecreased neutralization activity was subsequently confirmed in several studies.. On April 4, Pfizer-BioNTech's latest information on a vaccine trial in South Africa showed that the vaccine was so far 1% effective (that is, no cases occurred in vaccinated subjects).Placebo control groupStates that 9 of the 6 infections were B.1.351..
January 2021 in South AfricaAd26.COV2.S vaccineJohnson & Johnson, who conducted a clinical trial in South Africa, reported that the level of protection against moderate to severe COVID-19 infection was 72% in the United States and 57% in South Africa..
September 2, "Financial Times』\ Paper is from South Africa Oxford UniversityInterim study data from a study conducted in collaboration with AZD1222 reported that the Oxford-AstraZeneca vaccine (AZD1.351) showed reduced efficacy against B.XNUMX...The study found that in a sample size of 2,000 people, the AZD1222 vaccine provided "minimal protection" in all cases except the most severe cases of COVID-19... On February 2, the South African Health Minister canceled about a million vaccine deployment plans while reviewing the data and waiting for advice on how to proceed..
Gamma strain (lineage P.1)
Strain P.1 (20J / 501Y.V3), the first mutant identified in Brazil, may have partially escaped the effects of Pfizer-BioNTech vaccination..
Strain B.1.617 (Delta strain / Kappa strain)
In October 2020, a new double mutant was discovered in India and named strain B.10. Almost undetected until January 1.617 and in AprilAntarcticaとSouth American continentSpread to at least 20 countries on each continent except..Among the approximately 15 defined mutations, this is the spike mutation D111D (synonymous), G142D., P681R, E484Q, L452R And the latter two are easyantibodyMay cause to avoid(* There is no mutation in G1.617.2D and E142Q in strain B.484 described later, but instead there is a mutation in T478K).
The Delta strain has a high viral load and is said to be highly infectious.Even if the vaccine is given, the risk of infection is higher than that of the conventional strain, while the risk of aggravation is kept low due to the effect of the vaccine.In addition, it has been pointed out that even if the vaccinated person is infected, even if it is mild or asymptomatic, it may proliferate in large quantities in the body like the non-vaccinated person and become a source of virus infection..
Clinical trials and approval status
In the Phase I study, safety and preliminary doses were tested mainly in dozens of healthy subjects, and in the Phase II study, immunogenicity and dosage were tested following the success of the Phase I study. level(BiomarkerEfficacy based on), and side effects of candidate vaccines are evaluated, usually in hundreds of people.Phase I–II trials consist of preliminary safety and immunogenicity trials, usually randomized, placebo-controlled trials to determine more accurate and effective doses.Phase III trials typically involve more subjects at multiple institutions,Control groupAt the optimal dose, includingAdverse effectsTest the effectiveness of vaccines to prevent disease while monitoring (“intervention trials” or “pivotal trials”)..Vaccine safety, efficacy, and in Phase III trialsDefinitions may vary depending on the company's trials, such as the degree of side effects, the definition of infection or dose, and whether the vaccine prevents moderate or severe COVID-19 infection..
Plans for ongoing clinical trials, if accumulating data in the trial provides positive or negative early insight into the effectiveness of the treatment.May be changed as..Indications for ongoing Phase II-III clinical trials for candidate vaccines can shorten study duration, reduce subject numbers, expedite early termination or success decisions, avoid duplication of research efforts, and Strengthen coordination on plan changes for solidarity trials between international hubs.
List of approved or approved vaccines
|Vaccine candidate drug, developer, investor||Developing country||Vaccine type (technology)||Inoculation interval||Storage temperature||Current phase (number of subjects)||Number of approvals||Number of emergency use permits|
|Oxford AstraZeneca COVID-19 Vaccine (Vaxzevria, Kobi Shield) [A]|
OxfordDe University,AstraZeneca, CEPI
|英国||Adenovirus vector (ChAdOx1)||2 times|
|2-8 ℃||Phase III (30,000)||2||143|
|Pfizer-BioNTech COVID-19 Vaccine (Cominati, Tojinameran)|
|USA, Germany||RNA (modRNATheLipid nanoparticlesDisperse to)||2 times|
|-70 ± 10 ℃||Phase III (43,448)||5||93|
|Sputnik V COVID-19 vaccine (Gam-COVID-Vac)||Russia||Adenovirus vector (, Ad5 and Ad26 types)||2 times|
|-18 ℃ (freezer)||Phase III (40,000)||2||6|
|Moderna COVID-19 vaccine |
|米 国||RNA (modRNATheLipid nanoparticlesDisperse to)||2 times|
|-20 ± 5 ℃ (freezer)||Phase III (30,000)||2||50|
Shino Farm: Beijing Biological Products Institute
|Chugoku||Inactivated COVID-2 (Vero cell)||2 times|
|2-8 ℃||Phase III (48,000)||4||50|
|Johnson & Johnson COVID-19 Vaccine |
Janssen Pharma,Johnson & Johnson,BIDMC
|United States, Netherlands||Adenovirus vector (, Ad26)||1 times||2-8 ℃||Phase III (40,000)||0||46|
|Chugoku||Inactivated COVID-2 (Vero cell)||2 times|
|2-8 ℃||Phase III (33,620)||1||32|
|India||Inactivated COVID-2 (Vero cell)||2 times|
|2-8 ℃||Phase III (25,800)||0||14|
|Chugoku||Adenovirus vector (, Ad5)||1 times||2-8 ℃||Phase III (40,000)||1||5|
|Russia||Subunit (peptide)||2 times|
|2-8 ℃||Phase III (40,000)||1||2|
Anhui Zhifei Longcom Biopharmaceutical Co. Ltd.
|Chugoku||Subunit vaccine()||3 times|
|Phase III (29,000)||0||2|
Shino Farm: Wuhan Biological Products Research Institute
|Chugoku||Inactivated COVID-2 (Vero cell)||1 times[Source required]||Phase III (51,600)||0||2|
The Chumakov Center at the Russian Academy of Sciences
|Russia||Inactivated COVID-2||2 times|
|2-8 ℃||Phase III (3,000)||0||1|
Research Institute for Biological Safety Problems
|Eur-lex.europa.eu eur-lex.europa.eu||Inactivated COVID-2||2 times|
|2-8 ℃||Phase III (3,000)||0||1|
|Sputnik Light||Russia||Adenovirus vector (, Ad26 type)||1 times||2-8 ℃||Phase III (7,000)||0||3|
|(English: MVC-COV1901）||Taiwan||Subunit vaccine(S-2P protein + CpG 1018)||2 times|
|2-8 ℃||Phase III (5,120)||0||1|
- ^ Oxford name: ChAdOx1 nCoV-19. Manufacturing in Brazil to be carried out by.
- ^ Long-term storage temperature. The Pfizer–BioNTech COVID-19 vaccine can be kept between -25 and -15 ° C (-13 and 5 ° F) for up to two weeks before use, and between 2 and 8 ° C (36) and 46 ° F) for up to five days before use.
- ^ Manufacturing partnership with the and Canadian Center for Vaccinology,, Nova Scotia
Vaccine candidates in human clinical trials
As of 2020, 11 of the vaccine candidates under clinical development are using adjuvants to increase immunogenicity..Immune adjuvantIs a substance that is added to vaccines to enhance the immune response to antigens such as COVID-19 virus and influenza virus...Specifically, adjuvants can be used to formulate COVID-19 vaccine candidates to increase their immunogenicity and efficacy to reduce or prevent COVID-19 infection in vaccinated individuals... The adjuvants used in the formulation of COVID-19 vaccines may be particularly effective in techniques using inactivated COVID-19 virus and recombinant protein-based or vector-based vaccines...Known as alumAluminum saltIs the first adjuvant used in an approved vaccine and is the adjuvant of choice in about 80% of adjuvanted vaccines...Alum adjuvant initiates diverse molecular and cellular mechanisms to enhance immunogenicity, including the release of inflammatory cytokines.
According to one expert, an effective vaccine against COVID-19 can save trillions of dollars in global economic impact, so the cost of billions of dollars looks small compared to that...In the early stages of a pandemic, it is not known if a safe, reliable, and affordable vaccine against the virus can be produced, and exactly how much it will cost to develop the vaccine. Was..Billions of dollars could be invested without success.
Once an effective vaccine is developed, billions of vaccines need to be produced and distributed worldwide. In April 2020, the Gates Foundation estimates that manufacturing and distribution will cost as much as US $ 4 billion...84-90% of vaccine candidates in Phase I clinical trials Did not reach final approval during development, and 25.7% did not reach approval in Phase III clinical trials..Manufacturers' investments in vaccine candidates exceed US $ 10 billion, and millions of doses can be wasted if advanced manufacturing contracts are signed..
As of November 2020, companies subsidized under the US Operation Warp Speed program have set an initial price of $ 11 to $ 1 per flu vaccine. doing.. In December 2020, a Belgian politician briefly published a confidential price agreed between vaccine producers and the EU. :
|Manufacturer||vaccine||Price per dose in the EU|
|AstraZeneca||Oxford-AstraZeneca COVID-19 Vaccine||€ 1.78|
|Johnson & Johnson||Johnson & Johnson COVID-19 Vaccine||US$ 8.50|
|Sanofi / GSK||€ 7.56|
|Pfizer / Biontech||Pfizer-BioNTech COVID-19 Vaccine||€ 12.00|
|R-Pharm||Sputnik V COVID-19 vaccine||US$ 10.00|
|Moderna||Moderna COVID-19 vaccine||US$ 18.00|
To deploy COVID-2021 vaccination after 19, 100-190 billion bottles (Vial) Global transportation and tracking may be required, and this effort is easily the largest everSupply chainBecomes an issue.. As of September 2020, Supply Chain and Logistics (logistics) Experts have expressed concern that the international and domestic networks for the distribution of licensed vaccines are not ready to respond in both quantity and urgency.The reason is mainly in 2020PandemicDue to resource deterioration during downsizing that reduces the lockdown and supply capacity of.. The COVAX (The COVID-19 Vaccines Global Access) partnership, global pharmaceutical companies, contract vaccine manufacturers, cross-border transportation, storage facilities, national health agencies, and many other organizations are facing global coordination. About issuesGAVI OfChief executive officer(CEO)States as follows. "Efficient delivery of billions of vaccines worldwide involves highly complex logistical and programmatic obstacles along the supply chain.".
As an example of emphasizing the size of the taskInternational Air Transport AssociationTransports only a single dose to people in more than 19 countries experiencing the COVID-200 pandemic, with 1 aircraft747A type freighter (introduced a precision vaccine cold storage device) is required... "In a fast-moving pandemic, if everyone isn't safe, no one is safe," GAVI said..
In contrast to multi-billion dollar investments in vaccine technology and early-stage clinical research, the vaccine's post-licensing supply chain has not received similar planning, coordination, security, or investment...The main concern isLow and middle income countriesVaccine distribution resources, especially for vaccination of children, are scarce or absent... In September, the COVAX partnership included 9 countries coordinating plans to optimize their COVID-172 vaccine supply chain.,UNICEF(UNICEF) will work with COVAX to prepare funding and supply chains for vaccination of children in 92 developing countries..
Logistics services for vaccination ensure the necessary equipment, staff and supply of licensed vaccines across international borders...At the core of logistics is the handling and monitoring of vaccines,Cold chainIncludes management, distribution safety within the vaccination network, etc... The purpose of the COVAX facility is to integrate manufacturing, transportation and overall supply chain infrastructure, centralize and equally manage logistics resources among participating countries...Includes logistics tools for vaccine forecasting and needs estimation, domestic vaccine management, potential waste, and inventory management.
- Individual vaccineVialThebarcodeVisibility and traceability
- Sharing of supplier audits
- Vaccine vial transport from manufacture to recipientEvidence preservationSharing
- Use of vaccine temperature monitoring tools
- Temperature stability test and guarantee
- New packaging and delivery technology
- Adjustment of supplies in each country (Personal Protective Equipment (PPE),, Syringe, needle, rubber stopper, freezer power supply, waste disposal, etc.
- Communication technology
- Environmental impact of each country
According to one vaccine developer, a lack of logistics at any stage could derail the entire supply chain...If the vaccine supply chain fails, the economic and human costs of a pandemic can be prolonged over the years..
As of August 2020, months after the establishment of safety and efficacy, many governments have more than US $ 8 billion, despite some vaccine candidates entering Phase III trials. Pre-ordered more than 50 billion vaccines at a cost..2021 vaccine pre-orders from the UK Government were 1 per person.. In September, CEPI provided financial support for basic and clinical research on nine vaccine candidates under a funding commitment to produce two billion doses of three vaccines approved by the end of 9. ing.2022 A total of 70-100 billion COVID-19 vaccines could be produced worldwide by now, but large pre-orders (called "vaccine nationalism") by rich countries are vaccines in poorer countries. It threatens the use.
After joining COVAX in October, China announced that it would produce 10 million vaccines by the end of 2020 and another 6 billion vaccines in 2021, but 10 billion people are home to it. It was unclear how many vaccines would be produced for the population of.Shino FarmThe company states that it may have a production capacity of over 2021 billion doses in 10.. Sinovac will complete its second production facility by the end of 2020CoronaVacIt says it aims to increase its production capacity from the previous 3 million doses to 6 million doses..
AstraZenecaThe CEO said: "The challenge is not the production of the vaccine itself,VialIs in filling.There are not enough vials in the world " In preparation for the high demand for vial manufacturing, an American glass maker invested $ 7 million for a vial factory in July.Although there are concerns about the availability of glass for vial production and the management of contaminantsShows rising manufacturing costs and diminished potential developer interests amid demand for affordable vaccines.
Vaccines must be handled and transported according to international regulations, maintained under different temperature controls by vaccine technology, and used for vaccination before they deteriorate during storage... The size of the COVID-19 vaccine supply chain is expected to be enormous to ensure global delivery to vulnerable populations...Priorities for preparing facilities for such distribution include optimization of temperature-controlled facilities and equipment, infrastructure, training of vaccination staff, and rigorous monitoring..RFIDThe technology is being implemented to track and certify vaccine dosages along the entire supply chain from manufacturer to vaccination..
2020 year 9 month,CompanyJohnson & JohnsonWith the companytechnology transferとAgreed to support the production of vaccine candidates, including production.. In October 2020, a partner scheduled to manufacture the first dose in December 10Lonza GroupBut in SwitzerlandAnnounced to manufacture vaccine candidate moderna..The newly constructed 2,000-square-meter facility will begin production at 3 million doses annually.The products manufactured here will be shipped frozen at -70 ° C to Laboratorios Farmacéuticos Rovi SA in Spain for the final stages of production...Lonza's base in Portsmouth, New Hampshire aims to begin producing US-specific vaccine ingredients as early as November..
Vaccines (and adjuvants) are inherently unstable to temperature changes and are throughout the supply chain.Cold chainRequires control and is usually kept at a temperature of 2-8 ° C (36-46 ° F).. The technology of the COVID-19 vaccine is diverse among several new technologies, so cold chain management presents new challenges, and some vaccines that are stable during freezing but are sensitive to heat should be frozen. Some vaccines are not, and some are stable above temperature...Freezing damage and lack of personnel training in the on-site inoculation process are major concerns...If multiple COVID-19 vaccines are approved, the cold chain of vaccines may have to address all of these temperature sensitivities between different countries, where climatic conditions and local resources for temperature maintenance change. Have sex.Shino FarmAnd Sinovac's vaccine is an example of an inactivated vaccine in Phase III trials that can be transported using existing cold chain systems, but CoronaVac itself does not need to be frozen..
The modRNA vaccine technology under development is difficult to control for mass production and degradation and may require storage and transportation at very low temperatures...As an example, Moderna's RNA vaccine candidates would have a limited shelf life if cold chain management was performed at sub-zero temperatures. BioNTech-Pfizer RNA candidates require storage below -70 ° C during transport storage from vaccine production to inoculation.
vaccineVialContains several doses of vaccine, but has a time limit after being punctured for the first dose and must be discarded after that, so it is suitable for local cold storage and management of the inoculation process. Need to pay attention.. Because COVID-19 vaccines are likely to be in short supply in many places during initial deployment, health authorities, agencies and vaccination staff are responsible for the supply of other well-supplied vaccines in general. It is required to avoid as much as 30% of corruption and disposal as much as possible..
Cold chains are also bikesDroneVaccine transport methods in local communities such as, the need for booster administration, the use of diluents, access to vulnerable people such as healthcare workers, children and the elderly are also challenges..
Supports long-term storage of vaccines in some countriesUltra low temperature freezerThe number ofSince the inoculation is in the summer, it is necessary to have cold storage equipment that can carry the vaccine in small portions from the freezer to the inoculation site, which is a heavy cost burden...Since many non-pharmaceutical specialists are involved at the end of the cold chain, there are cases where the low temperature cannot be maintained due to improper handling of equipment, resulting in disposal..
Air and land transportation
International air cargo coordination is an integral part of the time- and temperature-sensitive distribution of the COVID-19 vaccine, but as of September 2020, the air cargo network is not ready for multinational deployment... "Safe delivery of the COVID-19 vaccine will be the mission of this century for the global air cargo industry, but it cannot be achieved without careful prior planning, and the time is now. I. We urge governments to take the lead in facilitating cooperation across the logistics chain to prepare facilities, security arrangements, and border procedures for challenging and complex tasks. To "International Air Transport Association(IATA) Executive Director and CEOSaid in September 2020.
In 2020, due to a severe decrease in passenger air traffic, airlines will cut headcount to keep costs down (Layoff), Reducing routes, storing and selling aircraft, etc... As a leader in the procurement and supply of COVID-19 vaccine within the WHO COVAX facilityGAVI AllianceとUNICEFIs preparing for the largest and fastest vaccine deployment to date, with international air freight transport cooperation, customs and border control, and 1 aircraft to deliver a single vaccine to multiple countries. May require freighter.
Security and corruption
Widespread demand for COVID-2,000 vaccines across the supply chain, as pharmaceuticals are the world's largest market and are worth about $ 19 billion annually.Counterfeit goods,theft,Bad business law,Cyber attackVulnerable to..The lack of a harmonious regulatory framework between countries, such as poor technical capacity to identify and track counterfeit and genuine vaccines, restricted access, and ineffective capacity, is vaccinated. May threaten the lives of others and perpetuate the COVID-19 pandemic..Tracking system technology used in packaging materials is used by manufacturers to track vaccine vials throughout the supply chain., Also digital and to ensure the security of the vaccination teamBiometricsUsing the tool.
National infrastructure development
Although WHO has an "effective vaccine management" system in place, This includes building priorities for preparing national and quasi-national personnel and facilities for vaccine distribution, including:
- Training staff to handle time- and temperature-sensitive vaccines
- Robust monitoring capabilities to optimize vaccine storage and transport
- Temperature controlled equipment / equipment
- Facilitate takeoff and landing clearance
- Of flight attendantsquarantineExemption from requirements
- Promotion of flexible operation for efficient domestic expansion
- Grant landing priority to maintain vaccine temperature requirements
Vaccine expiration date
Made by Pfizer as an exampleTojinameran, Pfizer-Biontech, BNT162b2, Kominati intramuscular injection) is valid from the date of manufacture even when stored in an ultra-low temperature freezer (minus 90 ° C-60 ° C).6 months(However, in the 2021th edition of the package insert of the vaccine issued on September 9, 10, the expiration date for storage at minus 6 ° C-90 ° C is from 60 months.9 monthsHas been extended to), Made by Moderna that can be stored in a general low temperature freezer (mRNA-1273, Spikebacks intramuscular injection), but the limit is about 2-3 months after arrival at the site.Inventories and distribution management with an eye on supply and demand are important.
By October 2021, in some developed countries, the second inoculation of residents will have reached a certain rate, the increase in the inoculation rate will reach a plateau, and there will be a surplus of vaccines that have been secured in advance. The outlook has come out.In Western countries, about 10 million doses are expected to expire by the end of 2, and in Japan, about 2021 million doses are expected to expire by the end of March 2.There is a call for the establishment of a framework for international compatibility with countries that lack surplus vaccines that are about to expire..
For Pfizer products, the expiration date has been extended to 9 months, but the expiration date is stamped for each product, and as a general rule, the expiration date of existing products will not be extended.However, Shimane PrefectureMatsueThen, according to the opinion of the city's vaccination committee by specialists, there is no problem with efficacy and safety, and it is a policy to continue vaccination as long as it is within the extended deadline..
Inoculation to children
The age at which a child should be vaccinated varies from country to country. As of November 2021CubaIs subject to vaccination from the age of 2, and the People's Republic of China has notified that vaccination is obligatory for those over 3 years old.Supplied in Chinaチリ,Cambodia,IndonesiaAllows inoculation over 6 years old.Centers for Disease Control and PreventionThe (CDC) announced on November 2021, 11 that it also recommends vaccination for people aged 2 to 5 years old, but even in Israel, which has been the fastest in the world to inoculate, people are cautious about vaccination for young people. Persistent.
There was a future risk to the manufacturer as no physical long-term safety could be confirmed.On the other hand, on February 2020, 2,Alex OtherThe U.S. Secretary of Health and Welfare has stated that the "Public Preparation and Emergency Preparedness Act" for medical measures against COVID-19 (Public Readiness and Emergency Preparedness Act) ”Was published.The subject was "any vaccine used to treat, diagnose, cure, prevent or alleviate infection with COVID-19, or SARS-CoV-2 or its mutant virus," and the declaration was "manufacturer in vaccine production." Claims for the negligence of the medical provider who prescribes the wrong dose or the negligence of the medical provider are excluded unless there is intentional tort. "..This declaration is valid in the United States until October 2024, 10.
Social MediaThen, when the COVID-19 vaccine was not available, it was "already available".Conspiracy theoryWas also seen.Quoted in various SNS postsPatentIsSARS coronavirusExisting patents on gene sequences and vaccines of other strains such as COVID-19 are referenced, but not on COVID-XNUMX..
The United States, which was selling a vaccine called "nCoV2020 spike protein vaccine" on May 5, 21.SeattleTo North Coast Biologics, based inUS Food and Drug Administration(FDA) announces that it has sent a notice of cancellation.
Australian Institute for Strategic Policy(ASPI) is involved in a vaccine developed in the WestFake newsOr claim that propaganda is being disseminated by China and Russia...International NGO "Digital Hate Countermeasure Center" sends anti-vaccine in English-speaking countriesInfluencerPoints out that may be making huge profits from advertisements etc.
Some hoaxes about other vaccines include:
- infertilitybecome[Note 1].
- For corona vaccineRFID tag,MicrochipIs mixed inGovernment manages humans by embedding tags and chips.
- When you inoculate the corona vaccineBluetoothTo peripherals throughインターネットBe connected.
- 5G communicationConnected to.
- The bodymagnetbecome.
- Human immunodeficiency virusInfected with (HIV)
- Humans after vaccination with mRNA vaccineDNAIs modified.
- The governmentGenetic manipulationTrying to.
2021 year 7 month 19 dayYomiuri ShimbunOnline coverage Then, "English NPO"Anti-Digital Hate Center (CCDH)According to the survey, 65% of the hoaxes related to vaccines on SNS originate from 12 individuals and groups. "United States Attorney GeneralRobert F. KennedyAlso includes his son Robert F. Kennedy Jr.As a countermeasure,Facebook,TwitterSo, deletion of information denied by the Health Organization, retweets and "iineMeasures such as suspension of function are being taken.
Misinformation in Japan
In Japan, Twitter posts stating that "vaccination will make you infertile" began to spread around February 2021, which was about the same time as the start of vaccination of medical professionals.Half of them start from 2 accounts (Tokyo University教授Fujio ToriumiOther claims also tended to be anti-globalization and conspiracy theories..
Chuo UniversityProject ProfessorKunihiko Takeda TheYouTubeAccording to the results of the UK vaccination, "If all 320 million Japanese high school students are vaccinated, there is a probability that 50 people will die or suffer side effects."However, in the United Kingdom, no deaths have been reported that have a causal relationship with the vaccination of Pfizer and AstraZeneca, and no corresponding side reactions have been reported, and Takeda's remarks are incorrect..
Also, in Japan, the number of deaths after vaccination announced by the Ministry of Health, Labor and Welfare is often quoted, and rumors such as "many people have died after COVID-19 vaccination and are dangerous" may be disseminated.However, the cases disclosed by the Ministry of Health, Labor and Welfare are only the number of cases reported based on the vaccine reaction suspicion reporting system, and the total number of people who died immediately after vaccination, or the causal relationship between vaccination and death was confirmed. Does not match the total number of people.
A similar rumor states that "most of the deaths after COVID-19 vaccination announced by the Ministry of Health, Labor and Welfare have been concluded that the causal relationship between vaccination and death is unknown, and such vaccines are unreliable." There is alsoBut this is in JapanAdministrative anatomyIt is also due to the problem that the number of cases is extremely small, which is not limited to the COVID-19 vaccine., Similar events have been occurring in influenza vaccines for some time...However, although it is a fact that the cause of death has not been directly investigated by autopsy as described above,placeboControl studies have already demonstrated that there is no difference in the frequency of serious adverse events between the vaccine and placebo groups..
Cases reported based on the vaccine reaction suspicion reporting system will be reported to the council of the Ministry of Health, Labor and Welfare and will be examined by experts.However, as of October 2021, there have been no cases in Japan where a causal relationship was found between vaccination with COVID-10 vaccine and death...For this reason, the Ministry of Health, Labor and Welfare has evaluated that "no serious safety concerns are found.", The Q & A site for the general public explains, "Many people have not died due to the vaccination with the new corona vaccine.".
In OsakaTsūtsukenThe neon sign of "Don't shoot if you shoot during the clinical trial" "Don't shoot" [Mom] And two falsified images were spread on Twitter in November 2. It seems that it has been tampered with to call for not inoculating the COVID-2021 vaccine, and the operating company has warned on official Twitter as a "malicious hoax"..
Treatment of vaccinated and non-vaccinated persons
In some countries, it is clearly stated whether the COVID-19 vaccine has been vaccinated or not, and depending on the type of occupation, vaccination is mandatory. The issue of what to do is also emerging.From January 2022, 1, the U.S. government announced on November 4, 100 that it will require vaccination for companies with 2021 or more employees...Prior to this, the countryNew York CityProtests took place when the company announced that employees who would not be vaccinated would be treated as unpaid leave (excluding medical and religious reasons)..
In Japan, the Ministry of Health, Labor and Welfare publishes guidelines for employment and recruitment on its website, which indicates that dismissal or suspension of employment is not allowed simply because of refusal of vaccination..
COVID-19 vaccineInoculation certificateSome countries issue (vaccine passports), Israel, which is the most inoculated in the world in February 2021, and China in March of the following year. However, it is said that each country will follow suit.As of April 4, the same year, some European countries (アイス ランド,エストニア,Cyprus,ジ ョ ー ジ ジ,Poland,ルーマニア), In Latin AmericaGuatemala,ベリーズ,Ecuador,Indian OceanIsland countrySeychellesCountries such as Japan have begun to lift the ban on travel entry for vaccine passport holders.However, depending on the country, there are differences in effectiveness and ineffectiveness depending on the pharmaceutical company of the inoculated vaccine..
In Japan, from July 2021, 7, the fact of vaccination for overseas travelers will be announced.Officially certifiedStart accepting applications for issuance of certificates in each municipality.However, when returning to JapanquarantineThere is no relaxation of measures.
Vaccine security and inoculation status
The status of COVID-2021 vaccine in the world as of April 4, 10 is as follows..
Number of vaccinations per 100 people / Cumulative number of vaccinations
The status of COVID-2021 vaccine in the world as of April 9, 5 is as follows..
Number of vaccinations per 100 people / Cumulative number of vaccinations
As of September 2021, 9, the number of vaccinations per 5 people in Japan was 100, which has rapidly exceeded 107.5 million in less than half a year since March..
Regarding the vaccination rate in Japan, as of October 2021, 10, the number of people who received the second vaccination was 4% of the total population, and 2% when the first vaccination was completed... British statistics voluntary organization "According to the survey, the inoculation rate (population ratio statistics of the number of inoculated people) up to the number of inoculations planned by the health authorities of each country (usually 2 times, 3 times depending on the country) is based on the statistics as of October 10, the same year. It surpasses 17%, 66.47% in the United Kingdom, 65.7% in Germany, and 65.15% in the United States, which is comparable to the world..
As of March and April 2021, the COVID-3 vaccine per capita rate is the highest in the world.Israel.JewDiasporaFace political instability by leaking commitments from Pfizer executives to preferentially receive large doses of vaccines through a connection withNetanyahuMedia analyzed that it was the prime minister's recovery strategy.. The third inoculation was started in August 2021 and the fourth inoculation was started on January 8, 3..
On March 2021, 3, Lan Balichel, Israeli Corona Vaccine Specialist Team Representative and Chief Innovation Officer of Clarit, Israel's largest health organization, announcedJapan Press ClubAccording to what he said at the remote lecture hosted by、「昨年（2020年）の12月19日から高齢者優先で始まったワクチン接種は、16歳以上の全住民に対象が拡大され、イスラエル国民約920万人の60％が既に既に接種済みで、50％が2回接種済み。特に50歳以上は80％が2回目の接種を受けており、高齢者はワクチンで守られているThe reason why Israel was able to procure the vaccine earliest in the world was "I had a pre-purchase contract with a vaccine maker before December of last year. If the infection increases further, Pfizer and others I had a contract with the manufacturer to give priority to the vaccine. ".."Instead, the condition was that data on infections would be shared worldwide, which means that Israel could become a'testbed'for vaccination and procure important vaccines faster.".
Regarding the method of vaccination in Israel, "In Israel, vaccine clinics have been opened in various places for vaccination.He said that he had hundreds of clinics all over Israel in a week.Clinics were set up by setting up tents in large hospitals and plazas, and the management of inoculated people was digitized 1 years ago.Electronic medical recordIn Israel, he said that he decided who received the vaccination and the date and time of the second vaccination when he received the first vaccination.digitalizationRevealed that the progress made was very helpful for efficient vaccination..."It was important to ensure transparency. We told the public what we knew and what we didn't understand as a clear message... ".
Regarding the method of promoting vaccination, he explained, "People who have been vaccinated are given a'green badge'." "If you receive a mark certifying that you have been vaccinated on your smartphone, you can eat inside the restaurant and participate in concerts and cultural events. On the other hand, those who have not been vaccinated can go to the restaurant. By applying different rules to those who have been vaccinated and those who have not, such as saying that they can only eat outside the restaurant, economic activities can be resumed with peace of mind and the number of vaccinations will be increased.IncentiveIt also became ".
The United States of America
As of July 2021, the United States has a tendency to level off with a vaccination rate of 7% of the total population.President of the United StatesJoe BidenWas a speech on July 7 of the same year,United States Federal GovernmentLocal authorities have called on vaccinated people to pay $ 100 to encourage vaccination, and have announced that federal officials and employees of trading companies will be required to disclose vaccination status..
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- ^ Oshinto New Era Rough Sea of Information] (5) Related Articles "Giant Producing Anti-Vaccine Activities" Mainichi Shimbun, January 2022, 1, page 5
- ^ a b [Oshinto New Era Rough Sea of Information] (5) "Vaccine infertility" spread / Medical hoax SNS offense / defense / Small number of senders Impact"Mainichi Shimbun" morning edition January 2022, 1, page 5 (viewed January 1, 2022)
- ^ "Infertility when vaccinated?abortion?Expert "Don't be fooled by misinformation"”(Japanese). NHK (September 2021, 7). 2021/7/12Browse.
- ^ Schlea, Rachel (August 2021, 8). “Fact check for false information about new virus vaccine and pregnancy". BBC NEWS. British Broadcasting Corporation. 2021/9/9Browse.
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- ^ a b "[Gimon elimination! !!Vaccine Q & A] Is the "Corona Vaccine Conspiracy Theory" credible? "The body becomes a magnet" "Microchip is included" "Make infertility" etc.”(Japanese). zakzak (Evening Fuji） (September 2021, 7). 2021/7/16Browse.
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- ^ Hatachi, Kota. “"Vaccine for Japanese high school students, side effects such as 50 deaths or hemiplegia" is incorrect.Remarks by a university professor, played 30 times on YouTube”(Japanese). BuzzFeed. 2021/4/4Browse.
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- ^ "To doctors, etc.-Request for suspicion of adverse reactions to the new corona vaccine-". 2021/10/28Browse.
- ^ In the middle of this page, there is a statement that "For the time being, please actively consider reporting on the following symptoms in order to carry out a wide range of evaluations, including symptoms that have not been shown to have a causal relationship with vaccination." Yes, not all reported cases have a causal relationship with vaccination.In addition, the same page states, "If the symptoms do not lead to the diagnosis of anaphylaxis and do not meet the reporting criteria, they will not be subject to reporting." For example, a traffic accident immediately after receiving the vaccination. Of course, if you die from a large amount of bleeding due to bleeding, you will not be subject to reporting.
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- 2009 new influenza vaccine
- Drug research for COVID-19
- Drug diversion study for COVID-19
- Global pandemic of new coronavirus infections
- Neutralizing antibody
- Acquired immunity
- Collective immunity
- COVID-19 vaccines(English) --World Health Organization (WHO)
- COVAX(English) --World Health Organization (WHO)
- COVAX Facility(English) --Gavi
- Vaccines for COVID-19(English) - CDC
- Coronavirus (COVID-19) Vaccinations(English) --Oxox Martin School
- About the new corona vaccine -Ministry of Health, Labor and Welfare
- Corona Vaccine Navi -Ministry of Health, Labor and Welfare
- About the new corona vaccine - Prime Minister's Office
- Recommendations for COVID-19 vaccine - Japanese Society of Infectious Diseases
- Information about the new corona vaccine - National Institute of Infectious Diseases
- Research and development issues for the new coronavirus infection (COVID-19) - Japan Medical Research and Development Organization
- JPMA member companies' R & D efforts for therapeutic drugs and vaccines - Japan Pharmaceutical Manufacturers Association