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🏥 | Why "sleep" is so important for vaccination against viral diseases


Why "sleep" is so important for vaccination against viral diseases

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In addition, it has a great influence on the immune function.

The corona (COVID-19) vaccine, which is currently the most important issue in the world.The elderly inoculation has settled down, and the next is younger ... → Continue reading

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Immune system

Immune system(Men-ekikei,English: immune system) Means in vivoPathogenNon-self substances such ascancer cellBy recognizing and killing abnormal cells and foreign substances such assickIt is a mechanism that integrates a large number of mechanisms to protect from. This mechanismウ イ ル スからParasiteIt senses and functions a wide range of pathogens and foreign substances while distinguishing them from the healthy cells and tissues of the living body itself. In the immune system細胞,組織,organAre precisely and dynamically linked.

In order to overcome this difficult task and survive, there is no single mechanism for recognizing and neutralizing pathogens.進化did.BacteriaSimple likeUnicellular organismBut,Innate immunityVirus calledinfectionDefend酵素I have a system. Other basic immune systems are ancientEukaryoteEvolved inplant,Fishes,Reptiles,昆虫Remains in. Innate immunity is called defensinAntimicrobial peptidesIs a mechanism that involves, a phagocytic mechanism,[1] Complement system.

Human capitallikevertebrateIt is,Acquired immunityWe have evolved a more complex defense mechanism called. Acquired immunity is of many typesproteinConsists of dynamic interactions of cells, organs and tissues.This adaptation processImmune memoryTo create. Immune memory created from an initial response to a particular pathogen results in an enhanced response to a second encounter with the same particular pathogen. This process of acquired immunityvaccineIt is the basis of inoculation.

When the immune system becomes abnormal, it becomes more susceptible to diseases (infectious diseases, autoimmune diseases, allergies). If the immune system is less active than normal, immunodeficiency disease can occur, leading to repeated infections and life-threatening infections. Immunodeficiency disease is like severe combined immunodeficiency diseaseGenetic diseaseIs the result ofRetro virusCaused by an infectionAcquired immunodeficiency syndrome (AIDS)MedicineIs the cause. On the contrary, when the immune system is overactive,Autoimmune diseaseIs awakened. This results from increased immune system activity that attacks normal tissues as if they were alien species. As a common autoimmune diseaseRheumatoid arthritis,Systemic lupus erythematosus(Also with lupus erythematosus),Type I diabetes, There is. Allergies are called hypersensitivity and are caused by an excessive immune response.組織Damage to.AnaphylaxisThere is a shock and so on.

ImmunologyIs in all areas of the immune systemResearchCovering and humanHealthAnd is deeply related to illness. Further research in this area is to promote health and illness.治療Can also be expected.


What is immunity?Human capital,Animal"Different from myself" that has entered the bodyforeign body”(Non-self) of the living bodyHomeostasisIt is one of the maintenance mechanisms. In general,Drug,Chemical substanceTo eliminate suchliver Of酵素bymetabolismWorks, while immunity is better than thatHigh molecularIsprotein(Snake venom,Bee venomEtc.) and invaded the bodyPathogenOften works as a mechanism to eliminate. Especially due to pathogensinfectionIt is important as an infection defense mechanism to protect yourself from protection, and when simply called "immunity", this isInfection protection immunityOften refers to.

The immune systemInnate immunity(Congenital immunity, innate immunity,en: innate immune system)WhenAcquired immunity(Acquired immune system, adaptive immune system,en: adaptive immune system) And. Special in innate immunity細胞They are equipped with intruders that reproduce themselvesHostDiscover and eliminate pathogens in the body before they cause serious damage toProliferationIt can be dealt with before it causes serious harm to the host.

Acquired immunityantibody,complementDue to blood proteins such asHumoral immunitylymphocytesSuch as細胞byCellular immunityIs carried by. For lymphocytesDifferentiationMatureImmunoglobulinTo produceB cellsIn addition to the,ThymusDifferentiate withmatureToT cellsand so on. Other,PhagocytosisByantigenIs taken up, decomposed and presented to T cellsDendritic cellsEtc. are also involved in the expression of immune function. These cellsBone marrowProduced in the thymus andLymph node,spleenIt comes to function through interactions in lymphoid tissues such as.

The magnitude of the effect of both innate immunity and acquired immunity is self and non-self.分子It depends on whether the immune system has the ability to distinguish between the two. A self-body element that can be distinguished from foreign substances by the immune system.[2].. Foreign molecules that are distinguished from foreign substances by the immune system are called non-self molecules. One of the non-self molecules isantigen(Antigen; this isantibody gene(Abbreviation for erator), specific immunityReceptorDefined as a substance that binds to and induces an immune response[3].

Multi-layered defense

The immune systeminfectionProtects the living body with a multi-layered defense system while increasing its specificity. The simplest is the epithelial barrier,Bacteria,ウ イ ル スIs to prevent the invasion of the living body. PathogenWhen innate immunity (also called innate immunity) breaks through this barrier and invades the body, it is immediately detected and non-specifically eliminated. Innate immunity is everythingplantandAnimalRecognized in[4].. But if the pathogen escapes innate immunity wellvertebrateUnleashes a third-tier defensive reaction. This isAcquired immunityIt is activated by innate immunity once it comes into contact with the source of infection.The acquired immune system recognizes and attacks pathogens, but adapts its response to improve awareness of pathogens during infection.This mechanism remains in the immunological memory after the pathogen is eliminated, and is then strengthened each time the same (or very similar) pathogen is encountered, resulting in a faster and more powerful attack.[5].

Components of the immune system
ItemInnate immunityAcquired immunity
PathogenantibodyReaction ofNon-specific Non-specificSpecific
Time to maximum response after contactEliminate before contactShort (immediately)The first time is long (delayed to adapt to the pathogen), the second time is short (immediately)
Ingredients involvedCellular immunityCellular andHumoral immunity
Cell nameEpithelialWhite blood celllymphocytes
Immune memoryNoneNone (Immune memory #Innate immune memory)Yes
Distribution in the living worldAlmost all living thingsAlmost all living thingsVertebrates with jaws

Epithelial barrier

PathogenCells exposed toEpithelial(So-called皮膚だ け で な く,Mucosa,IntestineEtc.)Living bodyTheinfectionIt has a barrier that protects it from mechanical, chemical and biological protection.Surface barrier(en: Immune system #Surface barriers) Also.

Mechanical barrier

leafWaxiness seen inCuticle,昆虫 OfExoskeletonWas borneggShell ofmembraneAnd皮膚.. These are examples of mechanical barriers and are at the forefront of the line of defense against infection.[3].. The skinEpithelial, Outer layer,Genuine LeatherIt is composed of and mechanically blocks most infectious agents.

Howeverlung,IntestinesOperate other systems to protect openings that communicate with the outside world, such as the urinary tract. For example, with the lungstracheaThen,cough,sneezeWith the airflowCiliaBy the movement of, The urinary tractPee, Respiratory organs (such as the nasal cavity and respiratory tract) and digestive organs (such as the oral cavity and gastrointestinal tract) due to mucusmicroorganismCatch and entangle[6].

Chemical barrier

Chemical barrierinfectionWork for defense.皮膚It is,keratinRich in細胞Are closely arranged side by side. This isWedPlay the skinWeakly acidicTo keep the skinBacteria OfProliferationIt also works as a chemical barrier to suppress. Skin andBreatheThe tube is like β-defensinAntimicrobial peptidesSecrete[7]. saliva,,BreastmilkincludeLysozyme,Phospholipase A2Etc.酵素AlsoAntibacterialAn antibacterial substance that acts[8][9]. Vaginal discharge TheMenstruationEven slightly laterAcidicActs as a chemical barrier when leaning towardssemen ThePathogenKillingSpermine,Defensin,zincincluding[10][11]. Secretory fluidAsGastric juiceToStomach acidIs extremely lowpHWhile showingdigestive enzyme OfProteolytic enzymeIt has a strong chemical defense against ingested pathogens.

Biological barrier

ReproductionUreter,StomachIn the tubeSymbiosisdoingBacteriaPlexusPathogenNutrientsAnd breeding groundsPathogenCompete with and act as a biological barrier. in this case,pHAnd availableionlikeEnvironmentMay change[12].. This means that the pathogenOnsetUp to possible populationProliferationReduce the chances of being able to do it.IntestinesWithinIntestinal bacteriaIs working.YogurtUsually included inLactic acid bacteriaPure likecultureReintroduction of benign flora by children's intestinal tractinfectionAtmicroorganismBalance the groupHealthThere is evidence that it works to help keep things clean. This is bacterialGastroenteritis,Inflammatory bowel disease,Urinary-tract infectionGives hope to preliminary data on postoperative infection studies[13][14][15].

BacterialInfectionOften againstAntibioticsIs used, but most antibiotics act non-specifically on both pathogenic and normal bacteria,MoldIt doesn't work for antibioticsOral administrationByFungusAbnormally proliferates and vaginaCandidiasislikeMycosisMay cause[16].

Innate immunity

Pathogen EpithelialBreak through the barrier atmicroorganism,toxicityIf a substance can successfully enter the living body, then in the living bodyInnate immune systemConfront (congenital immune system). This is due to humoral, chemical and cellular barriersHostIt is a protection mechanism of.White blood cellAnd lymphocytes細胞And mechanisms are mobilized to protect the host, usually at that timeInflammatory reactionOccurs. In this innate immune response, the living body usually structures microorganisms.Pattern recognition receptorIt is activated when it is detected by. This structural pattern is conserved among a wide range of microbial groups[17].. Alternatively, the cell gives a warning signal when it is damaged. Many, but not all, of them are the same that recognize pathogensReceptorPerceived by[18].. Protected by the natural immune system is a comprehensive response to pathogens[3]..In other words, instead of responding to various pathogens separately, they always deal with them in a general-purpose manner, so the time to activate their effects is short, so to speak, they are always ready for battle.On the other hand, there is no immune memory like the acquired immune system, and it is not a mechanism to protect for a long time.

The natural immune system is the main system of host defense for most organisms[4],plant-Fungi-昆虫-Multicellular organism(mammalianHigher such asvertebrate(Except) is the main defense system. It also has a primitive life,進化It is considered to be an old defense method. Also,Toll-like receptor, Nod protein,RIG-I(PathogenesismicroorganismResearch on sensors for) has progressed since the end of the 20th century, and innate immunity has been promoted.Higher animalsIt is an important mechanism as a premise for the establishment of acquired immunity (for example).Macrophage,Dendritic cellsIs directly activated by the presence of the pathogen).

Fluid or chemical barrier


Inflammation ThePathogen OfinfectionIs one of the first responses of the immune system to or stimuli[19].. Signs of inflammation are ...pain,swellingOne of the組織Inflow tobloodCaused by an increase in.

InflammationinjuryOr infected細胞 secretionToEicosanoidCytokineIt is caused by chemical factors such as a specific group called, which is the normal response of the immune system to infection. For eicosanoidsProstaglandinIncludes, if this substance is associated with inflammation, with feverBlood vesselCause expansion. Also included in eicosanoidsLeukotrieneIs a kind ofWhite blood cellActs on (lymphocytes)[20][21].. For the types of cytokinesWhite blood cellInvolved in communication betweenInterleukin,ChemotaxisPromptMacrophageAnd so onChemokine, Of the host cellProtein synthesisLike stoppingウ イ ル スHas antiviral activity againstinterferonand so on[22].. Growth factors andCytotoxicityFactors toosecretionMay be done. These cytokines and otherChemical substanceMobilizes immune cells to the site of infection, eliminates pathogens, and then in any tissue damagedrepairUrge[23].

Complement system

Complement systemIs a biochemical cascade that assists (supplements) the antibody's ability to attack the surface of foreign cells or index them to be destroyed by other cells. What is complement?antibodyAuxiliary or complementary to the function ofproteinIs. More than 20 proteins involved, depending on the antibodyPathogenKillSupplement It was named to mean that it has the ability to strengthen. Complement is a major factor in the innate immune responsebody fluidMake a sexual element[24][25].. Many species have a complement system,mammalianNot onlyplant,Fishes,InvertebrateSomewhat primitive, such as part ofBiology But i have[26].

Human capitalSo this response is thesemicroorganismBy the binding of complement to the antibody attached to the microorganism, or on the surface of the microorganismcarbohydrateBy binding the complement protein toactivationWill be done. This cognitive signal triggers a prompt killing response[27].. It is the degree of signal enhancement caused by the subsequent activation of complement molecule proteolysis that determines the speed of the response. When many complement proteins are activated by proteolytic cleavageProtease(Proteolytic enzyme). After the complement protein attaches to the microorganism, the complement's own proteolytic enzyme activity is expressed, followed by activation of other complement proteolytic enzymes, which occurs continuously. this isCatalytic reactionCauses a cascading and positive first signalfeedbackIt is to strengthen while controlling with[28].. By the complement clinging in this wayCell membraneIs destroyed and the pathogen is killed[24].. Often due to complement activationinfectionCellularProtoplasmDestruction occurs, resulting in infected cellsDissolution, Causes the death of pathogens. The end product of the complement mechanismC5b6789Is another nameCell membrane damage complexIt is also called by destroying the infected cells and the cell membrane of the source of infection.,LysisWake up. thisImmunolytic phenomenonOrImmunolytic reactionIn the defense against bacteriaNeutrophilIt is an important mechanism along with the phagocytosis of. CascadepeptideTo attract immune cells,Blood vesselUpdates the permeability of the pathogenOpsonization(Coat) and mark it so that it can be destroyed. The complement system opsonizes (or coats) the surface of the pathogen, tagging it so that it is destroyed by other cells, inducing recovery of inflammatory cells, and neutralizing antigenic antibodies. Remove the complex debris.

Cell barrier

White blood cellWhichorgan,組織Not combined with, but a single細胞It is an organ consisting of and is independentUnicellular organismThe right arm of the innate immune system, which behaves like[3].. White blood cells of the innate immune system include mast cells, eosinophils, basophils, natural killer cells,PhagocytesIt has the ability to identify (macrophages, neutrophils, dendritic cells) and pathogens that can induce infection. These cellsPathogenRecognize and eliminate,microorganismSwallow and kill, or contact and attack larger pathogens[26].. Innate immunity works in the first stages of infection, but many sources have developed strategies to avoid innate immunity. Natural immune system cells are more important in specific adaptive acquired immunityMediatorIs[5],Antigen presentationIt can be activated by going through a process known as.

The phagocytic function plays an important role in cellular innate immunity and is performed by cells called phagocytic cells that swallow and eat pathogens and granules. Phagocytes phagocytose sources of infection and particles, ieEatIt plays a role of eliminating by doing so. Phagocytes usually circulate in the body looking for pathogens,CytokineGuided to a specific site by[3].. Once the pathogen is swallowed by phagocytes, it is intracellular called fargosome.VesicleCaptured by, followed byLysosomeIt fuses with another vesicle called to form a far lysosome. The pathogen isdigestive enzymeBy orBreatheFollow the burstFree radicalsKilled by release into fargolysosomes[29][30].. The phagocytic function has evolved to acquire nutrients, but in phagocytes this role has been expanded to act as a defense mechanism that includes pathogen phagocytosis.[31].. The phagocytic function is that phagocytesvertebrateAlsoInvertebrateProbably the oldest form of host defense, as it is also present in[32].

Neutrophils and macrophages are phagocytes that move throughout the body in search of invading pathogens.[33].. On macrophages and neutrophilsReceptorToBacteriaBacterial phagocytosis and destruction begin when molecules bind.

usuallyBlood flowIt exists inside and is the most abundant among phagocytes. Usually accounts for 50% to 60% of total circulating leukocytes[34].. Especially as a result of bacterial infectionInflammationNeutrophils in the acute phaseChemotaxisIt moves to the inflamed area by the process. In most cases, it is the first cell to arrive at the site of infection.
Tracking the source of infection that exists throughout the organization組織And put it in the intercellular space. With versatile cells酵素,complementProtein, andInterleukin-1Wide range of control factors such asChemical substanceTo produce[35].. Macrophages are corpses and dumpster diving (Scavenger) Also acts as a cell, removing useless cells in the body and other decaying deposits and activating the adaptive immune systemAntigen presenting cellsWork as[5].
Dendritic cells(DC; dendritic cell)
Get in touch with the outside world組織It is a phagocyte that exists in. Therefore, this cell is mainly皮膚,nose,lung,stomach,IntestinesExists in[36].. The name of this cell isNerve cell OfDendriteIt was named because it resembles (dendrite). Both nerve cells and dendritic cells have many dendrites,NerveNot involved in function. Dendritic cells are the key to the adaptive immune systemT cellsSince it presents an antigen to the immune system, it bridges innate immunity and acquired immunity.[36].
Natural killer cells(NK cells)
tumorCellular and viral infectionsGlandular cellsAttack and destroy[37](By the way, this is not included in the inflammatory reaction).
Related to neutrophils,ParasiteChemistry in defense againstMediatorThesecretionTo do. Also,asthmaSuch asAllergiesAlso involved in[38].
Mast cells(Mast cell)
Connective tissue,MucosaExists in infection protection andRecovery,InflammationControl the response[39].. This cell is the mostAllergiesAnaphylaxisBe involved in[34].

Specific and adaptive acquired immunity

Acquired immune systemIs the earlyvertebrateTo進化And cause a stronger immune response, individualPathogenIndicates that is of a particular typeantigenIt is a mechanism that discriminates and memorizes (immune memory) by[40].. The response is antigen-specific andAntigen presentationIt is necessary to recognize that it is a specific non-self antigen during the process called. Recognition of antigen specificity allows the activation of a coordinated response to a particular pathogen or cells infected with a particular pathogen. The ability to initiate such a coordinated response is retained by memory cells in the body. If the pathogen hits the body more than onceinfectionIf so, these specific memory cells are used to immediately eliminate the pathogen.


Involved in acquired immunity細胞Is of a particular typeWhite blood cellso,lymphocytesIt is called. Its main type isB cellsT cellsAndBone marrowInHematopoietic stem cellsDerived from[26].. B cellsHumoral immunityInvolved in the reaction, T cellsCellular immunityInvolved in the response. B cells and T cells recognize specific goalsReceptorHas a molecule. To recognize targets of "foreign bodies" such as pathogens, T cellsantigen(Pathogen) Is disassembled into small piecesSelfReceptorMajor histocompatibility complex(MHC,Major Histocompatibility Complex) Must be presented in combination with the molecule. For T cellsCytotoxic T cells(Killer T cells)Helper T cellsThere are two main subtypes. Cytotoxic T cellsMHC class I moleculeRecognizes only antigens bound to and helper T cellsMHC class II moleculeRecognizes only antigens bound to.These twoAntigen presentationMechanism reflects the different roles of the two types of T cells. As the third minor subtype of T cellsγδ T cellsRecognizes unprocessed antigens that do not bind to MHC receptors[41].

In contrast, B cell antigen-specific receptors are on the B cell surface.antibodyIt is a molecule that recognizes the entire pathogen without antigen processing. Antibodies on B cells are samples of antibodies that the B cells will produce in the future, but there are some differences. Each B cell proliferation system expresses a different antibody, and a complete set of B cell antigen receptors represents all the antibodies the body can make.[26].

Cytotoxic T cells (CTL)

Cytotoxic T cells(CTL, killer T cells)T cellsIn the subgroup ofウ イ ル ス(And otherPathogen)infectionDamaged, damaged, or dysfunctional細胞Kill[43]. B cellsLike, each type of T cell is differentantigenRecognize. Cytotoxic T cells are their own T cellsReceptor(TCR) Is another cellMHCIt is activated when it binds to a specific antigen that is complexing with a class I receptor. Recognition of this MHC-antigen complex is on T cellsCD8Helped by a co-receptor called. The T cells then migrate throughout the body in search of cells expressing MHC class I receptors that carry such antigens. When activated T cells come into contact with such cells,(English editionlikeCell injuryRelease the substance. Perforin is the target cellCell membraneMake a hole inion,water andtoxinInvade. (English edition(Proteolytic enzyme) Invasion of other toxic substances into target cellsApoptosisInduce[44].. Depends on T cellsHostCell killing is especially important in preventing viral replication. T cell activation is tightly regulated and is generally a very strong MHC-antigen complex activation signal.Helper T cellsRequires an additional activation signal by[44].

Helper T cells (Th)

Helper T cells(Th cells) regulate the immune response of both innate and adaptive immunity, and the body is specific.PathogenHelps determine which immune response to the[45][46]..Helper T cells have no ability to damage cells, do not kill dysfunctional cells, and do not directly eliminate pathogens.Instead, it controls the immune response by directing instructions to other immune cells.

Helper T cellsMHCBound to a class II moleculeantigenT cells that recognizeReceptor(TCR)Manifestationdoing. The MHC-antigen complex is the same helper T cellCD4Intra-T cells that are also recognized by co-receptors and act on T cell activation分子(For example(English edition) Is mobilized. The relationship between helper T cells with MHC: antigen complexCytotoxic T cellsWeaker. It is that cytotoxic T cells are activated by the intersection of one MHC: antigen complex molecule, whereas helper T cells are activated by a large number (about 1 to 200) of receptors, MHC: It means that the antigen complex must adhere. Also, for activation of helper T cells,Antigen presenting cellsAnd requires longer fellowship time[47].. Resting helper T cells affect the activity of many other cell types by activationCytokineFree. Cytokine signals released by helper T cells are macrophage signals.microorganismKilling and cytotoxic T cellsantibodyTo produceB cellsStrengthen the activities of[3].. In addition, helper T cell activation is a CD40 ligand (also known as CDXNUMX ligand).(English edition) Causes an increase in the amount of regulation of molecules expressed on the surface of T cells. This molecule acts as a typical additional stimulus signal required to activate antibody-producing B cells.[48].

γδ T cells

γδ T cellsIs a CD4+And CD8+Another T cell as opposed to a (αβ) T cellReceptorHelper T cells with (TCR),Cytotoxic T cells,andNK cellShare the same properties as. The conditions for obtaining a response from γδ T cells have not been completely elucidated. A subset of T cells with other unfamiliar mutant TCRs, such as CD1d-restrictiveNatural killer T cellsIt straddles a wide range between innate immunity and adaptive immunity.[49].. On the other hand, γδ T cells are TCR.geneIt is an element of adaptive immunity because it can reorganize to produce receptor diversity and also develop memory phenotypes. On the other hand, various subsets have restricted TCR or NK receptors.Pattern recognitionIt is part of the innate immune system because it may be used in. For example, a very large number of human Vγ9 / Vδ2 T cellsmicroorganismCommon produced by分子Respond within a few hours. More highly restricted Vδ1+ T cellsEpithelial cellsSeems to respond to the stress[50].

B cells and antibodies

1B cellsIs on the surfaceantibodyIs a specific outpatientantigenWhen combined withPathogenWill be recognized[51].. This antigen / antibody complex is taken up by B cells and is a proteinbreak downBy processpeptideBe made. B cells then specificize these antigenic peptidesMHCPresented on a class II molecule. The complex of MHC and antigen specifically binds to that antigenHelper T cellsAnd its helper T cells activate B cellsLymphocainEmit[52].. When B cells are activated and begin to divide for proliferation, their offspring (Plasma cells) Have millions of specific antibody copies that recognize this antigen分子Also produces and secretes.

These antibodiesBlood vesselPlasma andLymphatic vesselsEnter and circulate.antibodyThe substance ofImmunoglobulinCalledproteinIs expressing the antigenBacteriaIt specifically binds to pathogens such asComplement systemActivation orPhagocytesMark for uptake and destruction by. thisOpsonizationThat is. Antibodies are bacterial against invading pathogenstoxinOr combine withウ イ ル スDirectly by interfering with the receptors used by bacteria and bacteria to infect cellsneutralizeCan also be[53].

Alternative adaptive immune system

Classic of adaptive immunity分子(For exampleantibody,T cellsReceptor)Vertebrates with jawsDespite being only presentLamprey,EelPrimitive jawless likevertebrateA unique lymphocyte-derived molecule has been found in. These animals carry a large group of molecules called mutant lymphocyte receptors (VLRs), which are jaw-bearing vertebrate antigens.ReceptorOf a very small number (1 or 2) likegeneProduced only from. These molecules are in the same way as antibodiesPathogen OfantigenIs believed to bind to antibodies with the same degree of specificity[54].

Immune memory

B cellsT cellsRemains in the body for a long period of time in those progeny cells when they are activated and begin to replicateMemoryThere will be something that will become a cell.AnimalThroughout their lifetime, these memory cells are unique to eachPathogenIt retains the memory of encountering the pathogen and can trigger a powerful response when the pathogen is detected again. This is due to the pathogen throughout the life of the individualinfectionIt can be said to be "adapted" because it occurs in adaptation to and the immune system prepares for future contact.Immune memoryCan hold either in the form of short-term passive memory or in the form of long-term active memory.

Passive memory

Passive immunity passive immunity It is,antibody,Cytotoxic T cellsAn immune response caused by administration of an existing agent such as (CTL).

NewbornIn advancemicroorganismEspecially without contactinginfectionEasy to receive. There, the mother provides several levels of passive defense.妊娠Special type of medium antibodyIgG placentaDirectly from the mother viaFetusWill be shipped to. ThereforeHuman capitalNewbornBirthAlready have antibodies with the same range of antigen specificity as high-level mothers[55].BreastmilkAlso has antibodies in the babystomachTo protect against bacterial infections until the newborn can synthesize its own antibodies[56].. This passive immunity is usually short-lived and lasts only days to months, because the fetus does not actually make memory cells or antibodies and only borrows them from the mother.Medical scienceSo, defensive passive immunity is antibody-rich from one individual to anotherserumCan also be done by artificially transferring[57].

Active memory and immune treatment

Active immunity active immunity It is,vaccineSuch asantigenImmune response induced by administration.

long-termActiveMemory is after infectionB cellsandT cellsObtained by activation of. Active immunity is an artificial vaccineVaccinationCan be established by. The principle of vaccination (or called immune treatment) isPathogenIs to introduce the antigen of the immune system to stimulate the immune system to develop specific immunity against the specific pathogen and prevent the disease caused by the pathogen.[3].. This deliberate induction of the immune response has been successful by leveraging the naturally occurring specificity of the immune system and thus being able to induce immunity.Human capitalOne of the leading causes of death in the populationInfectionVaccine treatment is one of the most effective manipulations of the immune system developed by mankind.[58][26].

Most viral vaccines are based on live attenuated viruses, but many bacterial vaccines have no adverse effectspoisonIngredients of substances, etc.BacteriaBased on the non-cellular components of the components of[3].. Most bacterial vaccines are innate immune, as vaccines with antigens derived from many non-cellular components do not produce much adaptive immune response.Antigen presenting cellsTo activate and maximize immunogenicityAdjuvantProvided with the addition of[59].

Human immune disorders

The immune system has taken up specificity, inducibility, and adaptability to have a highly effective structure. However, host defense can fail, which can be divided into three broad categories. Immunodeficiency, autoimmunity, hypersensitivity.


Immunodeficiency occurs when one or more elements of the immune system fail. The immune systemPathogenThe ability to respond to is diminished young and old. Immune response is immune from around 50 years oldAgeingBegins to decline for[60][61].Developed countryThen.obesity,Alcoholism,DrugUse is a common cause of weakening immune function[61].. HoweverDeveloping countriesThen.MalnutritionIs the most common cause of immunodeficiency[61].. enoughproteinDo not takediet TheCellular immunity,complementActivity,Phagocytesfunction,IgAAntibody concentration,CytokineImpair production.NutrientsIsion,copper,zinc,selenium,vitaminA, C, E, B6,Folic acid(Vitamin B9) Is deficient in the immune response[61].. Plus when you are youngThymusTheHeredityOfmutationIs the cause of手術Loss of removal by means of severe immunodeficiency and very high infectivity[62].

Immunodeficiency is hereditaryAcquiredBut it can happen[3].. ChronicGranulomasIn illnessPhagocytesMay have weak pathogen destructive power, but hereditary orCongenitalAIDS and some examples of immunodeficiencycancerType causes acquired immunodeficiency[63][64].

Kind ofウ イ ル スImmune function is destroyed by infection with variousInfection-complicationsIllness that causesAcquired immunodeficiency syndrome(AIDS, AIDS). Also this virusHuman immunodeficiency virus Called (HIV). Immune function is congenitally disrupted, and diseases that cause various infectious diseases are collectivelyPrimary immunodeficiency syndromeCalled.


Enhanced immune response is one extreme of immunodeficiency, especially autoimmune diseases. Here, the immune system cannot accurately distinguish between self and non-self, and the body part of itselfattackTo do. Many under normal conditionsT cellsTheantibodyIs selfpeptideReact with[65].. special細胞(ThymusandBone marrowOne of the functions of (hidden in) is to present autoantigens produced in the body to young lymphocytes and eliminate cells recognized as autoantigens to prevent autoimmunity.[51].


Allergies (hypersensitivity) are self組織It is an immune response that damages the body. According to the Coombs classification, it can be divided into five types.

Type I allergy is an immediate reaction orAnaphylaxisThe reaction is often associated with allergies. Symptoms from mild discomfortdeadWide range up to. Type I allergyMast cells,BasophilSecretesIgEIs the cause[66].

Type II allergyantibodyOf its own cellsantigenToCombineIt comes from marking it to destroy it. this isAntibody-dependent enhancement of infection(ADE:British: Antibody-dependent enhancement, Cytotoxic hypersensitivity),IgG,IgMThe antibody is the cause[66].. Immune complex (antigen aggregation,complementDeposits of proteins, and IgG and IgM antibodies) in various tissues trigger a type III allergic reaction[66].

Type IV allergies (also known as cell-mediated or delayed allergies) usually take 2-3 days to develop. Type IV reactions are associated with many autoimmune diseasesInfectionSeen inContact dermatitis(IvySumac) May also be seen. It is the ones involved in these reactionsT cells, Monocytes andMacrophageIs[66].

Type V allergies have a similar mechanism to type II, except for the irritating part.Graves' diseaseIs a typical disease.

Other mechanism

InvertebrateDoes not produce lymphocytes andantibodyThe multi-element adaptive immune system is the first because it does not produce a humoral response based onvertebrateSeems to have occurred in[1].. However, many species utilize the mechanisms expressed as precursors to these aspects of vertebrate immunity. The immune systemBiology Seems to be even the simplest functional structure of.Bacteria TheBacteriophageと 呼 ば れ るウ イ ル スIt uses a unique defense mechanism called a restriction modification system to protect it from pathogens.[67].ProkaryotesAlso has an acquired immune system and has contacted in the pastPhage OfgenomeTo hold the fragmentCRISPRUsing an arrayRNA interferenceCan interfere with virus replication in the form of[68][69].

Pattern recognitionReceptorPathogenAccompanying分子It is used by almost all living things to detect. Called a defensinAntimicrobial peptidesIs all animals andplantOf the innate immune response seen in進化Is one of the elements preserved[1].Complement system,PhagocytesIs also used in most invertebrates.RibonucleaseAnd RNA interference reaction pathways are allEukaryoteIt is conserved in and is thought to play a role in the immune response to the virus.[70].

Unlike animals, plants lack phagocytes. Most plant immune responses have systemic chemical signals released by the plant[71].. When a part of a plant is infected, the plant undergoes a local hypersensitivity reaction. As a result, the cells at the infected site are swift.ApoptosisAnd prevent the spread of infection to other plants.Systemic acquired resistance(SAR; Systemic Acquired Resistance) is a type of defensive response that allows the entire plant to resist certain infectious agents.[71].. RNASilencingThe mechanism is particularly important for this systemic response as it can block viral replication.[72].

Tumor immunity

For other important roles of the immune systemtumorMay be found and eliminated. Tumor-transformed cells are normal細胞Not inantigenIs expressed. These antigens appear non-self to the immune system, and immune cellsTransformationAttacks tumor cells. By tumorManifestationThere are several sources of antigens to produce.Cervical cancerCauseHuman papillomaviruslikeCarcinogenic virusDerived[74][75].. Others are found only at low levels in normal cells, but self as seen at high levels in tumor cellsproteinIs. As an exampleTyrosinaseと 呼 ば れ る酵素There is some kind of expression when it is expressed at high levels皮膚Cells (egMelanosite)MelanomaConvert to tumor cells called[76][77].. The third possible source of tumor antigens is cells in normal cellsProliferationAnd proteins important for controlling survival are commonmutationTurns into a cancer-inducing molecule[74][78][79].

The main reaction of the immune system to tumors is abnormal cellsCytotoxic T cells(CTL) and sometimesHelper T cellsIs to destroy with the assistance of[77][80].. Tumor antigens are similar to viral antigensMHCPresented on class I molecules. This causes cytotoxic T cells (CTL) to consider tumor cells as abnormal.[81].NK cellSimilarly, it kills neoplastic cells and acts especially on tumor cells in which MHC class I molecules are expressed less than normal. This is a common phenomenon in tumor cells.[82].. Antibodies are often produced against tumor cellsComplement systemIs also attempted to destroy those cells[78].

Obviously, some tumors escape the immune system and go to cancer.[83].. Tumor cells often express low numbers of MHC class I molecules on their surface, thus avoiding detection by cytotoxic T cells (CTLs).[81].. In addition, some tumor cells release products that inhibit the immune response, such as cytokines.TGF-βWhen secretingMacrophageAnd lymphocyte activity is suppressed[84].. In addition to tumor cellsImmune toleranceMay develop and prevent the immune system from attacking tumor cells anymore[83].

Paradoxically, tumor cells lure macrophagesCytokineAnd macrophages with cytokines that then allow tumor cells to growGrowth factorsMacrophages can promote tumor growth when they produce[85].. In addition in tumor cellsHypoxiaTumor cells combine state and macrophage-producing cytokinesTransitionIt reduces the production of proteins that block the cancer and helps the cancer cells spread.

Physiological control

hormoneActs as an immunomodulator and may be able to alter the sensitivity of the immune system. For example, for womenSex hormoneAlso for adaptive immune responses[86] Also for the innate immune response[87] It is known to have immunostimulatory activity.Systemic lupus erythematosuslikeAutoimmune diseaseSelectively attacks women, but often onsetpubertyThere is a coincidence of time that it is. In contrasttestosteronelikeMale hormoneSeems to have immunosuppressive power[88].. Some other hormones appear to control the immune system, the most famous of which.Prolactin,Growth hormone,Vitamin DIs[89][90].. Hormone levels continue to decline over the years, causing a diminished immune response, especially for older people[91].. On the contrary, some hormones are controlled by the immune system, and as a prominent one,Thyroid hormoneIs controlled by the immune system[92].

The immune systemSleep,休息Enhanced by[93] stressDamaged by[94].

dietMay affect the immune system. For example freshfruit,Vegetables, Some kindfatty acidRich infood TheHealthMaintains and promotes the immune system[95].. In the same wayFetusUndernutrition can cause lifelong damage to the immune system[96]. traditionalMedical scienceThen.HerbsIt is believed that some of them stimulate the immune system. For such herbs, for exampleEchinacea,Licorice,Talus(Bead),Salvia,garlic,America·ElderberryFruit,Shiitake mushroom,Hyssop, And moreHoneyThere is. Studies suggest that such herbs stimulate the immune system, even though they act complexly and are difficult to characterize.[97].

Manipulation in medicine

The immune response is autoimmunity,Allergies, TransplantRejectionTo suppress the unwanted response that results from, and also largely escape the immune systemPathogenIt can be manipulated to stimulate the defense response against.vaccineInoculation andSerum therapyOf the immune systemAntigen-antibody reactionIs used.Immunosuppressive drug TheAutoimmune diseaseOr excessive組織Destruction is happeningInflammationUsed to control transplantation and to prevent transplant rejection after organ transplantation[26][98].

Anti-inflammatory drugIs often used to control the effects of inflammation.GlucocorticoidIs the most powerful of these chemicals. But these drugs have many unexpectedSide effectsCan have (eg, centrality)obesity,Hyperglycemia,osteoporosis). Use must be tightly controlled[99].. Therefore, use small amounts of anti-inflammatory drugsMethotrexate,AzathioprineIt is often used in combination with cytotoxic or immunosuppressive drugs such as. Cytotoxic drugs activateT cellsInhibits an immune response that kills dividing cells such as. However, since the killing action is indistinguishable, the cells that are constantly dividing and theirorganIs affected and this istoxicityBrings side effects[98].CyclosporineImmunosuppressive drugs such as block the signal transduction system and thus prevent T cells from responding correctly to the signal.[100].

Larger drugs (> 500Da) may neutralize the immune response, especially when given repeatedly and in large doses.bigpeptideandproteinThe effectiveness of chemicals based on (typically over 6,000 Da) is limited. The drug itself is not immunogenic and may be co-administered with immunogenic substances. Such a thingTaxolI sometimes see it. To predict the immunogenicity of peptides and proteinsComputerMethods have been developed, especially for treatmentantibodyDesign, potential toxicity to viral coat particlesmutationIt is useful for evaluating and verifying peptide-based drug treatment. Mainly in early techniquesEpitopeIn the areaHydrophilic Ofamino acid HydrophobicI relied on the observation that it was overexpressed than the amino acids in[101]In more recent research, computers are usually based on well-studied viral proteins, using it as a learning material for known epitopes.DatabaseRelies on computer-learned techniques for[102].. A publicly accessible database has been established for cataloging epitopes known to be recognized by B cells.[103].. ImmunogenicBioinformaticsThe field of study based on is newly born and is referred to as immunoinformatics.[104].

Manipulation of pathogens

PathogenSuccess depends on the ability of the host to escape the immune response. Therefore the pathogen works well for the hostinfectionWe have developed some methods that can be done while avoiding immune-mediated destruction.[105].. Bacteria often secrete it for physical barriers酵素digestionGet through by doing. For example, the use of the type II secretory system.[106].. AlternativelyType III secretion systemIs used to insert a tube that punctures the host cell. From pathogen to host directly through this tubeproteinTo move. Proteins transported through tubes are often used to stop host defense[107].

The avoidance strategy used by some pathogens to escape the natural immune system is intracellular replication (also called intracellular pathogenicity). In this case, the pathogen spends most of its life history in the host cell. There, immune cells,antibody,in additioncomplementIt is protected from them without direct contact with them. An example of an intracellular pathogenウ イ ル ス,Food poisoningBacterialSalmonella,Eukaryote OfParasiteIsmalariaWhat causesPlasmodium falciparum) AndLeishmaniasisWhat causesLeishmania spp.) and so on.Mycobacterium tuberculosis(Mycobacterium tuberculosis) Survives in protective capsules that block complement lysis[108].. Many pathogens secrete chemicals that weaken the host's immune response and misdirect[105].. Some bacteria are biological to protect against cells and proteins of the immune systemthe filmThere is something that forms. Such biological films are found in many successful infections, such asCystic fibrosisChronicPseudomonas aeruginosaInfection or(English editionHave an infection[109].. There are other bacteria that express surface proteins that bind to antibodies and reduce the efficacy of the antibodies. In this exampleStreptococcus(G protein),Staphylococcus aureus(),(English editionThere is ()[110].

The mechanism by which the virus escapes the adaptive immune system is more complicated. Easy way is essentialEpitopeIs to rapidly change epitopes on the surface of the virus that are hidden and completely non-essential (amino acids and / or sugars). For exampleHIVIs constantly a protein in the outer membrane of the virus that is essential for invading the host's target cellsmutationWake up. These frequent changes in antigens target these proteinsvaccineWill explain that you are failing. Masking antigens with host molecules is a common strategy for escaping host cells.[111].. In HIV, the outer membrane that covers the virus is made from the outermost membrane of the host cell. These "self-covering" viruses make it difficult for the immune system to recognize them as "non-self."[112].

Immunology and its history

ImmunologyIs a science that studies the structure and function of the immune system.

This was born out of medicine and early research was about the cause of immunity to disease. As far as we know, immunity was first mentioned.BC430 OfAthensDuring the epidemic.ThucydidesWrote that people who have previously recovered from their illness will not be affected twice by caring for their patients.[113].. The acquired immunity observed in this way was later explored by Louis Pasteur, leading to the development of vaccination and the proposal of microbial etiology of the disease.[114].. Pasteur's theory confronts the theory that was prevailing at the time of illness, and this proof was made in 1891.Robert KochKoch won the Nobel Prize in 1905, although he had to wait until it was proved that the microbes made by him were the cause of the infection.[115].. In 1901(English editionby,yellow feverWhen the virus was discovered, the virus was confirmed as[116].

Immunology has made great strides towards the end of the 19th century, but in the midst of rapid development the study of humoral and cell-mediated immunity[117] Of particular importancePaul EhrlichIn his work, he explained the specificity of the antigen-antibody reaction.Side chain theoryWas chanted.Humoral immunityContribution to understanding of cell-mediated immunity researchIlya MetynikovRecognized for receiving the 1908 Nobel Prize in collaboration with[118].


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